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Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives.
Int Neurourol J
February 2024
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Overactive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypotheses.
View Article and Find Full Text PDFPharmacological Profile of the Purinergic P2Y Receptors That Modulate, in Response to ADPβS, the Vasodepressor Sensory CGRPergic Outflow in Pithed Rats.
Pharmaceuticals (Basel)
March 2023
Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas Coapa, Deleg. Tlalpan, Ciudad de Mexico C.P. 14330, Mexico.
Calcitonin gene-related peptide (CGRP), an endogenous neuropeptide released from perivascular sensory nerves, exerts a powerful vasodilatation. Interestingly, adenosine triphosphate (ATP) stimulates the release of CGRP by activation of prejunctional P2X receptors, and adenosine 5'-O-2-thiodiphosphate (ADPβS), a stable adenosine diphosphate (ADP) analogue, produces vasodilator/vasodepressor responses by endothelial P2Y receptors. Since the role of ADP in the prejunctional modulation of the vasodepressor sensory CGRPergic drive and the receptors involved remain unknown, this study investigated whether ADPβS inhibits this CGRPergic drive.
View Article and Find Full Text PDFPharmacological characterisation of the CB receptor antagonist activity of cannabidiol in the rat vas deferens bioassay.
Eur J Pharmacol
October 2021
Cardiovascular Therapeutics Unit, Department of Biochemistry and Pharmacology, University of Melbourne, Victoria, 3010, Australia. Electronic address:
Cannabidiol is increasingly considered for treatment of a wide range of medical conditions. Binding studies suggest that cannabidiol binds to CB receptors. In the rat isolated vas deferens bioassay, a single electrical pulse causes a biphasic contraction from nerve-released ATP and noradrenaline.
View Article and Find Full Text PDFP2X3 receptors participate in purinergic inhibition of gastrointestinal smooth muscle.
Auton Neurosci
September 2021
University College London (UCL), Research Department of Neuroscience, Pharmacology & Physiology (NPP), Gower Street, London WC1E 6BT, United Kingdom. Electronic address:
The ATP analogue α,β-meATP is a potent relaxant of gastrointestinal smooth muscle, but its molecular target is uncertain inside the gut. α,β-meATP relaxed the carbachol-precontracted guinea-pig taenia coli in a concentration-dependent manner (EC, 2.0 ± 0.
View Article and Find Full Text PDFThe role of purinergic P2Y and P2Y receptors in ADPβS-induced inhibition of the cardioaccelerator sympathetic drive in pithed rats.
Purinergic Signal
March 2020
Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas Coapa, Deleg. Tlalpan, C.P. 14330, Ciudad de México, Mexico.
ATP is a cotransmitter released with other neurotransmitters from sympathetic nerves, where it stimulates purinergic receptors. Purinergic adenosine P receptors (coupled to G proteins) produce sympatho-inhibition in several autonomic effectors by prejunctional inhibition of neurotransmitter release. Similarly, signalling through P2Y and P2Y receptors coupled to G proteins is initiated by the ATP breakdown product ADP.
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