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Correlates of condom use among school-going Thai adolescents: the critical role of bullying victimizations.
BMC Psychiatry
January 2025
Department of Global Public Health and Primary Care, University of Bergen, Årstadveien 17, Bergen, 5009, Norway.
Background: Adolescents face numerous challenges that influence their sexual behaviors. Among these, bullying victimization is a critical yet understudied factor that may impact engagement in unprotected sex. This study investigated the correlates of condom use among school-going Thai adolescents, with a main focus on bullying victimization.
View Article and Find Full Text PDFDissecting the neuronal mechanisms of pinoresinol against methamphetamine addiction based on network and experimental pharmacology.
Phytomedicine
January 2025
Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, PR China; Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address:
Article Synopsis
- Addiction is a chronic brain disease associated with drug-seeking behavior, and Flos Daturae (FD) is being studied for its potential in addiction treatment, although its effective components are not well understood.
- The study aimed to investigate the impact of individual ingredients in FD on methamphetamine addiction, utilizing advanced techniques like LC-MS/MS, molecular docking, and behavioral experiments to identify specific targets and mechanisms.
- Findings revealed that pinoresinol (PINL), a key component of FD, effectively reduced methamphetamine-seeking behavior by specifically targeting the D1 dopamine receptor and its associated pathways, suggesting a targeted approach for addiction treatment.
Le diagnostic et la prise en charge de la syphilis congénitale : ne laisser passer aucune occasion.
Paediatr Child Health
November 2024
Société canadienne de pédiatrie, comité des maladies infectieuses et d'immunisation, Ottawa (Ontario).
La syphilis congénitale peut provoquer un arrêt de grossesse et une morbidité importante chez les nouveau-nés. L'épidémie actuelle de syphilis congénitale au Canada (particulièrement dans l'Ouest canadien) est une urgence sanitaire évitable. Les taux font foi d'un manque de contrôle de la syphilis dans la communauté et d'un manque de ressources de santé publique pour éviter une propagation qui s'est amorcée avant la pandémie de COVID-19.
View Article and Find Full Text PDFDiagnosis and management of congenital syphilis: Avoiding missed opportunities.
Paediatr Child Health
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Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario, Canada.
Congenital syphilis can result in pregnancy loss and substantial morbidity in newborns. The current epidemic of congenital syphilis in Canada (especially Western Canada) is a preventable public health emergency. Rates indicate a lack of control of syphilis within the community and insufficient public health resources to prevent spread that predate the COVID-19 pandemic.
View Article and Find Full Text PDFThe modulation of cholecystokinin receptor 1 in the NAc core input from VTA on METH-induced CPP acquisition.
Life Sci
January 2025
College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, China; Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, Hebei Province, China; Hainan Tropical Forensic Medicine Academician Workstation, Haikou, Hainan Province, China. Electronic address:
Article Synopsis
- - The study investigates how cholecystokinin (CCK) receptors, specifically CCK1 receptors, play a role in methamphetamine (METH)-induced addiction by affecting the nucleus accumbens core (NAcC) and its connections with other brain areas.
- - Using a mouse model, researchers created a condition that mimics METH addiction and explored the effects of genetically knocking out CCK receptor subtypes to understand their specific roles in the METH addiction process.
- - Results showed that disruption of CCK1R in NAcC hindered the development of METH-induced conditioned place preference and altered neuronal excitability, indicating that CCK1R is essential for the synaptic changes in the
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