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Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury.
Sci Rep
January 2025
Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2- 15 Yamada-oka, Osaka, 565-0871, Japan.
Circulating growth differentiation factor 15 (GDF-15) increases in response to inflammation and tissue damage. Its association with functional prognosis in cerebral infarction and subarachnoid hemorrhage is established; however, its role in traumatic brain injury (TBI) and its relationship with Sequential Organ Failure Assessment (SOFA) score, an indicator of systemic organ damage in TBI, remains unclear. This study aimed to explore the correlation between GDF-15 and functional outcomes at discharge in patients with TBI and stroke, including its association with SOFA scores in TBI.
View Article and Find Full Text PDFFour cardiomyopathy patients with a heterozygous DSG2 p.Arg119Ter variant.
Hum Genome Var
December 2024
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
DSG2, encoding desmoglein-2, is one of the causative genes of arrhythmogenic cardiomyopathy. We previously identified a homozygous DSG2 p.Arg119Ter stop-gain variant in a patient with juvenile-onset cardiomyopathy and advanced biventricular heart failure.
View Article and Find Full Text PDFUnderstanding the Past to Preserve the Future: Genomic Insights Into the Conservation Management of a Critically Endangered Waterbird.
Mol Ecol
January 2025
School of Ecology, Sun Yat-Sen University, Shenzhen, China.
To ensure the success of genetic rescue, we must minimise the potential negative effects of outbreeding depression that may arise from selecting source populations. The difficulty in assessing the likelihood of outbreeding depression has hindered its consideration in endangered species conservation. However, genomic research offers feasible indications.
View Article and Find Full Text PDFSemiconductor Transistor-Based Detection of Epithelial-Mesenchymal Transition via Weak Acid-Induced Proton Perturbation.
ACS Biomater Sci Eng
January 2025
Graduate School of Science and Engineering, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan.
Article Synopsis
- Developing new methods to detect the epithelial-mesenchymal transition (EMT) is important for studying tissue growth and cancer spread, as traditional methods are often slow and ineffective.
- This study introduces a pH perturbation technique that detects tight junction barrier disruptions during EMT by measuring proton leakage using a specialized pH-responsive semiconductor.
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A case of malignant lymphoma of the extrahepatic bile duct diagnosed by detailed imaging examination and endoscopic ultrasound-guided fine needle aspiration.
Clin J Gastroenterol
November 2024
Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
A 70-year-old woman presented to our hospital with abdominal pain. Imaging examinations showed diffuse and extensive wall thickening at the perihilar bile duct; however, the degree of stricture was mild, and the mucosal epithelium was smooth. A transpapillary biopsy was performed considering cholangiocarcinoma and IgG4 sclerosing cholangitis as differential diagnoses; however, no pathologic diagnosis was obtained.
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