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| http://dx.doi.org/10.1308/rcsann.2009.91.5.439a | DOI Listing |
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Evaluation of a novel silicone oil free primary packaging system with PTFE-based barrier stopper for biologics.
Eur J Pharm Biopharm
September 2023
Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:
In order to overcome silicone oil related problems for biopharmaceuticals, novel container systems are of interest with a focus on the reduction, fixation or complete avoidance of silicone oil in the primary container. Ultimately, silicone oil free (SOF) container systems made from cyclic olefin (co-)polymer or glass combined with the respective silicone-oil free plungers were developed. In the following study we evaluated the potential of a SOF container system based on a glass barrel in combination with a fluoropolymer coated syringe plunger.
View Article and Find Full Text PDFRelative suitability of DMSO and NaHCO3 for reversal of RISUG® induced long-term contraception.
Andrology
March 2016
Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, India.
Article Synopsis
- RISUG(®) is a reversible sperm inhibition method being tested as an alternative to traditional vasectomy, showing promise in long-term contraception and currently undergoing phase-III clinical trials.* -
- In a study on albino rats, two agents (DMSO and NaHCO3) were tested for reversing RISUG-induced sperm blockage, with DMSO showing fertility restoration at 45 days and NaHCO3 at 30 days.* -
- Results indicated variable fertility outcomes, with NaHCO3 enabling quicker recovery of fertility compared to DMSO, while the overall procedure was deemed successful, feasible, and safe for up to the F1 generation.*
Development, in vitro and in vivo evaluation of novel injectable smart gels of azithromycin for chronic periodontitis.
Curr Drug Deliv
April 2013
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
Periodontitis is an inflammatory condition affecting teeth resulting in progressive destruction of periodontal ligaments, resorption of alveolar bone and loss of teeth. Treatment of periodontitis includes surgical and non surgical management. Systemic antibiotics are also used for the treatment of periodontitis.
View Article and Find Full Text PDFLong-term effect of gamma irradiation on the functional properties and cytocompatibility of multiblock co-polymer films.
J Biomater Sci Polym Ed
May 2016
a Department of Drug Sciences , University of Pavia, Viale Taramelli 12 , 27100 , Pavia , Italy.
The purpose of this work was to investigate the long-term effect of gamma-irradiation treatment on the functional properties of PEG-PDLLA and PEG-PLGA films and to evaluate the cytocompatibility of sterilized samples. Chemical and thermal properties, and cytocompatibility of sterilized films were detected for samples at time zero and after storage at 5 ± 3°C for 60 days. An in vitro degradation study was carried out on polymer samples to examine the effect of sterilization on the degradation performances of co-polymer films.
View Article and Find Full Text PDFRapid isothermal substrate microfabrication of a biocompatible thermoplastic elastomer for cellular contact guidance.
Acta Biomater
June 2011
Industrial Materials Institute, National Research Council, Boucherville, QC, Canada J4B 6Y4.
The use of microstructured substrates to study and influence cell orientation, which plays an important role in tissue functionality, has been of great interest lately. Silicon and poly(dimethylsiloxane) substrates have typically been used, but long processing times and exogenous protein surface coating, required to enhance cell viability, limit their use as large-scale platforms. There is thus a need for a non-biodegradable biocompatible substrate that allows rapid and low cost microfabrication.
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