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New insights into Smad3 in cardiac fibrosis.
Gene
March 2025
Liaocheng Vocational and Technical College, Shandong, China. Electronic address:
Damage to myocardial tissues, leading to myocardial fibrosis, is a significant pathological hallmark across various heart diseases. SMAD3, a central transcriptional regulator within the transforming growth factor-beta (TGF-β) signaling pathway, plays a pivotal role in the pathological progression of myocardial fibrosis and cardiac remodeling. It intricately regulates physiological and pathological processes encompassing cell proliferation, differentiation, tissue repair, and fibrosis.
View Article and Find Full Text PDFThe frequency of CD3+ lymphocytes in non-myocarditis endomyocardial biopsies.
Cardiovasc Pathol
March 2025
Cardiovascular Pathology, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Lymphocytic myocarditis is a serious disease with significant morbidity and mortality. Cardiovascular pathology has an important role in its diagnosis, a diagnosis historically made using the presence of a lymphocytic infiltrate and myocyte injury (Dallas Criteria). The European Society of Cardiology (ESC) criteria, additionally, use a threshold of immune cells, determined by CD3 immunohistochemical stains to render the diagnosis of myocarditis on endomyocardial biopsy.
View Article and Find Full Text PDFMacrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditis.
Biol Direct
March 2025
Department of Pediatric Cardiology, Cheeloo Colledge of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Background: Viral myocarditis (VMC) is an inflammatory myocardial condition triggered by viral infections which involves pathogenic-related damage and immune-mediated damage. However, the precise immunopathogenic mechanisms underlying VMC remain elusive.
Methods: We performed single-cell RNA sequencing on mouse hearts during the acute phase of CVB3-induced VMC.
Infection-related mortality in hospitalized children: A multi-center study in China from 2016 to 2021.
J Infect Public Health
March 2025
Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children, Beijing, China; Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:
Background: Hospitalized children experience mortality as a result of infections. Since the COVID-19 outbreak in early 2020, China's strict prevention measures have curbed pathogen transmission, altering infection-related epidemiology. The Futang Research Center of Pediatric Development has collected the face sheet of discharge medical records (FSMRs) data from 27 tertiary children's hospitals since January 2016, which facilitate us to investigate this issue.
View Article and Find Full Text PDFHealth-related quality of life in adolescents with myocarditis and pericarditis after BNT162b2 COVID-19 vaccination: Korean national surveillance.
Eur J Cardiovasc Nurs
March 2025
College of Nursing, Chungnam National University, Building N1, Munwharo 266, Jungu, 35015 Daejeon, Korea.
Aims: Concerns have been raised regarding the potential causal relationship between myocarditis and mRNA COVID-19 vaccines. In response, the Korea Disease Control and Prevention Agency actively monitored myocarditis and pericarditis in adolescents who received mRNA COVID-19 vaccines in South Korea. Understanding the long-term health outcomes of these cases is essential for developing evidence-based national health policies.
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