Purpose: The aim of this study was to evaluate the in vivo tissue response to low-pressure plasma-pretreated collagen-I-coated titanium implant in a middle-term mouse model.
Methods: Plasma-treated collagen-coated titanium implants were transplanted into the dorsal skinfold chambers of BALB/c mice. Untreated, regular titanium implant material served as control. The neovascularization (functional vessel density) of the implant border zone and of the surrounding muscle tissue was analysed by intravital fluorescence microscopy. Additional histological analysis was performed to observe the inflammatory reaction.
Results: Statistical analysis revealed that the vessel density in the border zone of the implants was significantly enhanced in the plasma-treated collagen-I-coated group compared to controls. The histological examination of the two groups confirmed that the inflammatory response to the collagen-coated titanium implants was reduced compared to controls.
Conclusion: Plasma pretreatment and collagen I coating of titanium implant material leads to an enhanced tissue vascularization and a reduced inflammatory response.
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