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Vasoactive Intestinal Polypeptide Secreting MS Neuroblastoma.
J Indian Assoc Pediatr Surg
November 2024
Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
We present a rare case of a 17-month-old child diagnosed with MS-stage neuroblastoma and associated chronic diarrhea due to elevated vasoactive intestinal peptide (VIP) levels. The unusual occurrence of a VIP-secreting tumor in a patient with MS neuroblastoma is a rare combination, not previously reported in the literature. The patient underwent exploratory laparotomy and excision of the tumor, leading to a significant decline in VIP levels and resolution of symptoms.
View Article and Find Full Text PDFCarcinoid heart findings in vasoactive intestinal peptide-secreting tumour.
BMJ Case Rep
November 2024
Division of Cardiology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
Article Synopsis
- - Diagnosis of tricuspid valve disease in patients with carcinoid heart syndrome is often done with echocardiography, especially in those already diagnosed with carcinoid syndrome.
- - VIPoma is a rare type of tumor occurring in 0.05%-2% of cases, causing symptoms like flushing, diarrhea, and electrolyte issues without typically affecting heart valves.
- - In a notable case, detection of tricuspid regurgitation and stenosis during echocardiography led to a quicker investigation for cancer, ultimately revealing the presence of VIPoma.
VIPoma: An Unusual Cause of Chronic Diarrhea.
Acta Medica (Hradec Kralove)
October 2024
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chronic diarrhea is a significant challenge in clinical practice because of its high prevalence and various causes. Comprehensive clinical assessment and stepwise laboratory approach are crucial for an accurate diagnosis. This report presents a case of an adult woman who experienced chronic watery diarrhea, complicated by renal impairment and multiple electrolyte imbalances, including hypokalemia, hypophosphatemia, and metabolic acidosis.
View Article and Find Full Text PDFEfficacy of Racecadotril in a Patient Affected by a Therapy-Refractory VIPoma and Carcinoid Syndrome.
JCEM Case Rep
October 2024
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Article Synopsis
- - Neuroendocrine neoplasms (NENs) are diverse tumors from neuroendocrine cells, with about 30% causing hormone-related syndromes that can significantly impact patient health beyond the tumor size itself.
- - A 49-year-old male patient with an ileal NEN exhibited concurrent VIP and serotonin release, leading to a severe diarrhea syndrome after receiving peptide-radio-receptor therapy, despite ongoing medical treatments.
- - As traditional treatment options were no longer effective, an off-label use of racecadotril helped manage the patient's condition, allowing him to leave the ICU after five days of treatment.
Vasoactive Intestinal Peptide-Producing Neuroblastic Tumors: A Rare Cause of Refractory Diarrhea.
Cureus
August 2024
Pediatric Oncology, Grupo de Apoio ao Adolescente e a Criança com Câncer (GRAACC) / Universidade Federal de São Paulo (UNIFESP), Sao Paulo, BRA.
Neuroblastic tumors are the most common malignant extracranial solid tumors of childhood. A small subgroup presents chronic incoercible diarrhea due to the tumor's production of vasoactive intestinal peptide (VIP). The hypothesis of an occult tumor is not always considered, which delays and impairs treatment.
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