Objective: To profile the expression of transforming growth factor-beta1 (TGF-beta1) and its receptors (TGF-beta R1 and TGF-beta R2) in human fimbriae tubes to valuate the role of TGF-beta 1 signal system in adhesions and atresias formation of infertile women's fimbriae tubes.
Methods: The expressions of TGF-beta 1 and its receptors (TGF-beta R1 and TGF-beta R2) in fimbriae tubes were measured by immunohistochemical SP methods in 30 human fimbriae tube with adhesions and 15 cases without adhesions. The average integrated optical density (IOD) value of positive staining was tested by Image pro-plus 6.0 software. The results were analyzed with independ-samples T test and Pearson correlation.
Results: TGF-beta 1, TGF-beta R1 and TGF-beta R2 chiefly expressed in the epithelial cells, also expressed in the vascular endothelial cells and fibroblasts. Compared with human fimbriae tubes without adhesions or atresias, the expression of these three molecules all increased significantly in adhesion cases (P<0.05). In adhesion group, there was a positive correlation between TGF-beta 1 and TGF-beta R1, TGF-beta 1 and TGF-beta R2 (P<0.05), but no correlation between TGF-beta R1 and TGF-beta R2 (P<0.05), while there was no correlation among these three factors in control group.
Conclusion: TGF-beta 1 signal system may be an important ring-joint in adhesions formation of human fimbriae tube.
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