Objective: to evaluate the benefit of a participative educative strategy (PES) in the development of clinical skills to study patients with fever of unknown origin (CAFUO) by internal medicine residents (IMR).
Methods: twenty-two IMR participated. They were distributed at random in two groups; group I received passive strategy and group II received PES. Assessment tool consisted of 144 items of multiple choice questions using six clinical cases. The assessment was discussed and answered by 10 internal medicine specialists and a pilot test with 15 medical students was performed. The tests were applied pre- and post-exhibition of the strategy.
Results: there were no differences between groups, or in pre- and post-strategy, neither in the same group. Pre-strategy did not demonstrate differences between both groups. In group II, the post-strategy showed difference in the global results. The evaluation of each clinical case by group showed in group I there was statistical difference in case 2; in group II (experimental) there was difference in cases 1, 2, 4 and 6.
Conclusions: both strategies were useful, the residents developed comparable aptitude.
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World J Surg
January 2025
Precision Medicine Program, Hoag Family Cancer Institute, Newport Beach, California, USA.
Background: A recent prospective phase II study (ECOG-ACRIN E2211) demonstrated that MGMT deficiency was associated with a significant response to capecitabine and temozolomide (CAPTEM) in pancreatic neuroendocrine neoplasms (NENs); however, routine MGMT analysis in NENs was not recommended. Our study sought to demonstrate whether loss of MGMT protein expression is associated with improved overall survival (OS) in patients receiving CAPTEM for NENs from various tumor sites.
Materials And Methods: Paraffin-embedded tumor samples were evaluated by immunohistochemistry (IHC) using an MGMT monoclonal antibody.
Vet Res
January 2025
Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Porcine deltacoronavirus (PDCoV), also known as HKU15, is a swine enteropathogenic virus that is believed to have originated in birds. PDCoV belongs to the genus Deltacoronavirus (DCoV), the members of which have mostly been identified in diverse avian species. We recently reported that chicken or porcine aminopeptidase N (APN), the major cellular receptor for PDCoV, can mediate cellular entry via three pseudotyped retroviruses displaying spike proteins from three avian DCoVs (HKU11, HKU13, and HKU17).
View Article and Find Full Text PDFNat Commun
January 2025
Macromolecular Machines Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
The MCM motor of the eukaryotic replicative helicase is loaded as a double hexamer onto DNA by the Origin Recognition Complex (ORC), Cdc6, and Cdt1. ATP binding supports formation of the ORC-Cdc6-Cdt1-MCM (OCCM) helicase-recruitment complex where ORC-Cdc6 and one MCM hexamer form two juxtaposed rings around duplex DNA. ATP hydrolysis by MCM completes MCM loading but the mechanism is unknown.
View Article and Find Full Text PDFISA Trans
January 2025
School of Electrical Engineering, University of Jinan, Jinan, Shandong 250022, China. Electronic address:
This paper focuses on the issue of global practical tracking control by output feedback for uncertain nonlinear systems with unknown control coefficients and unknown reference signal. Unlike other tracking works, the upper and lower bounds of the unknown control coefficients in the studied nonlinear system are not required to be known, while the nonlinearities are bounded by the unmeasured states multiplying an unknown constant, the polynomial-of-output and the polynomial-of-input. Inspired by related works, an adaptive tracking controller based on a new dynamic high gain has been successfully constructed by combining the universal control idea and the concept of dead-zone with backstepping technique, which effectively handles the impacts of multiple uncertainties.
View Article and Find Full Text PDFCorticocortical (CC) projections in the visual system facilitate hierarchical processing of sensory information. In addition to direct CC connections, indirect cortico-thalamo-cortical (CTC) pathways through the pulvinar nucleus of the thalamus can relay sensory signals and mediate cortical interactions according to behavioral demands. While the pulvinar connects extensively to the entire visual cortex, it is unknown whether transthalamic pathways link all cortical areas or whether they follow systematic organizational rules.
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