Melanosis refers to abnormal or excessive deposition of melanin pigment in the cells and/or tissue, which can be seen in any organ but commonly in skin and oral mucosa. Melanosis of the urinary bladder is an extremely rare benign condition and only a handful of cases been reported in the English literature before. In this article, we report a new case of urinary melanosis, describe the differential diagnostic features from pseudomelanosis and offer clues for correct diagnosis. We also provide comprehensive review of the literature on the subject.
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http://dx.doi.org/10.1186/1746-1596-4-24 | DOI Listing |
BMJ Case Rep
January 2025
Obstetric and Gynecology, The Aga Khan University Hospital, Karachi, Sindh, Pakistan.
A nulliparous female presented with lower abdominal pain, initially diagnosed as incisional scar hernia, which was repaired. However, her pain persisted despite unremarkable radiology imaging. She was then diagnosed with anterior cutaneous nerve entrapment syndrome (ACNES) and underwent a right-sided ilioinguinal and iliohypogastric nerve block.
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March 2025
Department of Rheumatology and Immunology, People's Hospital of Longhua, Shenzhen, Guangdong 518109, P.R. China.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex etiology primarily linked to abnormalities in B lymphocytes within the human body, resulting in the production of numerous pathogenic autoantibodies. Telitacicept is a relatively novel humanized, recombinant transmembrane activator, calcium modulator and cyclophilin ligand interactor fused with the Fc portion (TACI-Fc). It works by competitively inhibiting the TACI site, neutralizing the activity of B-cell lymphocyte stimulator and A proliferation-inducing ligand.
View Article and Find Full Text PDFCureus
December 2024
Department of Family Medicine, Ministry of the National Guard-Health Affairs, King Abdulaziz Medical City, King Abdullah International Medical Research Center, Jeddah, SAU.
In the growing field of geriatric psychiatry, the "3 Ds"-depression, dementia, and delirium-are a complex clinical challenge, especially in patients with medical comorbidities. This is a case report of a 96-year-old Saudi woman with chronic kidney disease, heart failure, and recurrent hyponatremia presented with worsening sleep, depression, persecutory delusions, and hallucinations following an intensive care unit (ICU) stay for urinary tract infection. Examination revealed cognitive decline and depressive symptoms, with sodium at 123 mmol/L.
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December 2024
Orthopedic Surgery, King Fahad Medical City, Riyadh, SAU.
Ankle fractures, often accompanied by other injuries and complications, pose a significant healthcare burden due to their high incidence and associated treatment challenges. This case report investigates the use of Cytal™ Wound Matrix, derived from urinary bladder matrix (UBM), in managing postoperative complications following open reduction and internal fixation (ORIF) of a trimalleolar ankle fracture. A 57-year-old male with a history of hypertension sustained a trimalleolar ankle fracture following a road traffic accident.
View Article and Find Full Text PDFScand J Clin Lab Invest
January 2025
Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Crystals in urinary sediment are commonly recognized structures, typically identified by a combination of crystal morphology and urine pH. In this paper, we present the first reported case of EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene) crystals, the primary metabolite of methadone, in a 67-year-old male with hepatorenal syndrome. Routine urinalysis revealed numerous needle-shaped crystals, which prompted further investigation.
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