Purpose: The objective is to determine the usefulness of cathepsin L (Cat L) activity derived from the stratum corneum as an index of skin conditions by comparing the cheek and the forearm, in 20 female young adults.
Methods: The sebum quantity, hydration index, melanin index and pH were measured with a sensor system consisting of a sebumeter, a corneometer, a mexameter and a pH meter. The stratum corneum was collected using tape stripping. Cat L and total protein (TP) were analyzed and the Cat L/TP ratio was calculated.
Results: Our results indicated that (i) chronic sun exposure causes an increase in Cat L activity; and (ii) in order to cancel out the influence of the collecting technique, it is very important to measure the Cat L/TP ratio.
Conclusion: It is considered that the Cat L/TP ratio may be a useful index of the skin conditions in humans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0846.2009.00373.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Smart core-shell microneedles for psoriasis therapy: In situ self-assembly of calcium ion-coordinated dexamethasone hydrogel.
J Control Release
January 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511443, China. Electronic address:
Psoriasis is a prevalent relapsing dermatological condition that often necessitates lifelong treatment. The distinctive thickening of the stratum corneum presents a challenge to drug penetration. The employment of microneedles has been demonstrated to enhance the transdermal drug delivery efficacy by creating multiple microchannels in the skin.
View Article and Find Full Text PDFHighly Accurate, Non-Invasive Early Identification of Infants with a Filaggrin Loss-of-Function Mutation by in vivo Raman Spectroscopy, followed from birth to 12 months.
Ann Allergy Asthma Immunol
January 2025
Children's Health Ireland (CHI) at Crumlin, Dublin D12 N512, Ireland. Electronic address:
Background: Loss-of-function FLG-mutation (FLGmut) carriers are at increased risk of developing atopic dermatitis (AD), characterized by earlier onset and more severe disease. AD is driven by a complex interplay between skin barrier function, Th2 and Th2 dominant immune dysregulation and dysbiosis. Results from the STOP AD study suggest two early, initiating AD-pathogenetic pathways; a FLGmut-related skin barrier deficiency pathway, and an immune function-related inflammatory pathway.
View Article and Find Full Text PDFTransethosomes: A Comprehensive Review of Ultra-Deformable Vesicular Systems for Enhanced Transdermal Drug Delivery.
AAPS PharmSciTech
January 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
The transdermal route is one of the effective routes for delivering drugs. It also overcomes many limitations associated with oral delivery. One of the limitations of this route is the drug's poor skin permeability-stratum corneum, the skin's outermost layer that also acts as a barrier for the drug to penetrate.
View Article and Find Full Text PDFThumb-sized 3D-Printed cymbal microneedle array (CyMA) for enhanced transdermal drug delivery.
Eur J Pharm Biopharm
January 2025
School of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China; Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address:
Transdermal drug delivery presents a compelling alternative to both needle injection and oral ingestion of medication, as it enhances patient adherence and convenience through its non-invasive and painless administration method. The use of microneedles penetrates the barrier of the stratum corneum, facilitating the sustained delivery of drugs across the skin. However, their efficacy has been limited by the slow diffusion of molecules and often requires external triggers.
View Article and Find Full Text PDFDaily topical application of chlorhexidine gluconate to the skin in dogs and its impact on skin barriers and cytotoxicity.
J Vet Med Sci
January 2025
Faculty of Veterinary Medicine, Okayama University of Science.
In recent years, the importance of using local disinfectants instead of systemic antibiotics for the treatment of infectious skin diseases to prevent the emergence of resistant bacteria has become widely recognized. Chlorhexidine gluconate (CHG) is commonly used in veterinary antibacterial shampoos; however, the daily topical application of diluted CHG solutions has also been adopted. Despite its widespread use, few studies have investigated the effects of CHG on the canine skin barrier.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!