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The Purple Tomato Story; From Laboratory Bench to the Consumer.
ACS Food Sci Technol
January 2025
John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K.
A world apart from academic research, the path from developing a polyphenol-rich crop to a product available to consumers is not one taken by many research scientists. Here we review the steps taken to commercialize anthocyanin-enriched purple tomatoes in the USA. In describing some of the difficulties encountered and the work that was necessary for a successful commercial launch of a new biotech product, we hope to encourage others to believe that there is a viable route to market, and an appetite for polyphenol-enriched foods that can protect health.
View Article and Find Full Text PDFMediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults.
World J Psychiatry
January 2025
School of Medicine, Huzhou University, Huzhou 313000, Zhejiang Province, China.
Background: Frailty has become a significant public health issue. The recent increase in the number of frail older adults has led to increased attention being paid to psychological care services in communities. The social isolation of pre-frail older adults can impact their psychological distress.
View Article and Find Full Text PDFEGFR inhibitors plus dabrafenib and trametinib in patients with EGFR-mutant lung cancer and resistance mediated by BRAF mutation: a multi-center real-world experience in China.
Transl Lung Cancer Res
December 2024
Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Background: The combination therapy of the B-Raf proto-oncogene (BRAF) inhibitor dabrafenib and the mitogen-activated protein kinase kinase (MEK) inhibitor Trametinib has shown favorable outcomes in patients initially identified with BRAF mutations. However, there are currently no large-scale study data focusing on the use of a triple therapy regimen of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) plus dabrafenib and trametinib in patients with newly concomitant BRAF mutations after acquiring resistance to EGFR-TKIs. Our study aimed to explore the efficacy and safety of the triple therapy regimen through a multi-center real-world experience.
View Article and Find Full Text PDFComparing voluntary and government-mandated management measures for meeting sustainable fishing targets.
J Environ Manage
January 2025
Marine Stewardship Council, London, UK.
Management of natural resources and environmental systems has often involved top-down approaches in which government agencies set and enforce regulations on extractive activities. More recently, market-driven approaches were introduced to incentivise producers to voluntarily engage in practices that align with management objectives and support regulations. For the first time, we compare government and voluntary approaches within fisheries management systems and quantify their relative influences on the sustainability status of fish populations.
View Article and Find Full Text PDFAssessment of the Potential Clinical and Economic Impact of Weight Loss in the Adult Population with Obesity and Associated Comorbidities in Spain.
Adv Ther
January 2025
Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge-IDIBELL, C/de la Feixa Llarga S/N, 08907, Hospitalet de Llobregat, Barcelona, Spain.
Introduction: Obesity and its complications are associated with high morbidity/mortality and a significant healthcare cost burden in Spain. It is therefore essential to know the potential clinical and economic benefits of reducing obesity. The objective of this study is to predict the decrease in rates of onset of potential complications associated with obesity and the cost savings after a weight loss of 15% over 10 years in Spain.
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