Background: Placental site trophoblastic tumor, a type of gestational trophoblastic disease, is a rare tumor composed of intermediate trophoblasts.
Case: We report the case of a 47-year-old woman with 1 year of amenorrhea who presented with cough in the absence of gynecologic symptoms. She was found to have diffuse pulmonary metastases that were nonhypermetabolic on positron emission tomography (PET) scan. She was diagnosed with Stage 3 metastatic placental site trophoblastic tumor 12 years after her most recent pregnancy.
Conclusion: Placental site trophoblastic tumor is an unusual malignancy that may present remotely from antecedent gestational events. The relatively slow growth rate of this tumor may explain the lack of PET findings in our case.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/AOG.0b013e31819db2fe | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cyclocurcumin potently inhibits human aromatase as a potential therapeutic agent.
J Steroid Biochem Mol Biol
December 2024
Department of Obstetrics and Gynecology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address:
Curcuminoids, including curcumin and its derivatives, show potent inhibition of aromatase (CYP19A1), crucial for estradiol synthesis and breast cancer metastasis. Our study evaluated the efficacy and mechanism of 10 curcuminoids and their metabolites against human and rat CYP19A1 using placental microsomes, revealing species-specific IC values. Cyclocurcumin (IC, 4.
View Article and Find Full Text PDFPlacental cord insertion migration: Implications for ultrasound documentation and follow-up of abnormal placental cord insertion site.
Australas J Ultrasound Med
November 2024
Discipline of Medical Radiation Science, Curtin Medical School Curtin University Perth Western Australia 6845 Australia.
Introduction/purpose: It is well-documented in the literature that the placenta migrates during pregnancy; however, studies regarding placental cord insertion (PCI) migration are scarce. This longitudinal, prospective study aimed to determine whether PCI migration is a true phenomenon, to assess whether the PCI can change classification during pregnancy and to determine the validity of PCI site documentation including follow-up of abnormal PCI.
Methods: Eighty-three participants who had first, second and third trimester ultrasound examinations at a Western Australian private imaging practice over a 12-month period between November 2021 and November 2022 were recruited.
ICAM-1 expression is upregulated in the umbilical vein endothelial cells in acute chorioamnionitis with foetal inflammatory response.
Malays J Pathol
December 2024
Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Pathology, 56000 Kuala Lumpur, Malaysia.
Introduction: ICAM-1 is an adhesion molecule expressed on the endothelial cells and is involved in regulating leukocyte recruitment to the site of inflammation. Elevated ICAM-1 mRNA expression was found in the serum of mothers with chorioamnionitis. This study aimed to determine the expression of ICAM-1 in the placenta and umbilical cord of pregnancy with chorioamnionitis, and its association with adverse neonatal outcome.
View Article and Find Full Text PDFA case of transient hyperthyroidism induced by placental site trophoblastic tumor.
J Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunkyō, Japan.
We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29-year-old gravida 2 para 2 woman presented with abnormal genital bleeding 6 months after delivery. Endometrial histology suggested PSTT.
View Article and Find Full Text PDFTherapeutic potential of placenta-derived stem cells cultivated on noggin-loaded nanochitosan/polypyrrole-alginate conductive scaffold to restore spinal cord injury.
Stem Cell Res Ther
December 2024
Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: Spinal cord injury (SCI) is a severe and permanent nerve damage condition that poses significant burdens on individuals and society. Various therapeutic approaches have been explored to mitigate the consequences of SCI. Tissue engineering and regenerative medicine have emerged as a promising avenue for addressing this issue.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!