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Impact of hypokalemia on Brugada syndrome: case report unveiling mechanisms beyond QT interval prolongation.
Egypt Heart J
October 2024
Department of Cardiology and Vascular Medicine, Faculty Medicine, Gorontalo State University,, Jalan Jend, Sudirman No.6, Dulalowo Kecamatan Kota Tengah Kota, Gorontalo, 96128, Indonesia.
Article Synopsis
- Brugada syndrome (BrS) increases the risk of sudden death due to dangerous heart rhythms and is characterized by specific ECG changes, notably ST-segment elevation in right precordial leads.
- A case involving a 51-year-old man with low potassium levels (hypokalemia) revealed that while treatment normalized potassium, the Brugada pattern on ECG remained unchanged, and his corrected QT interval was shorter during hypokalemia.
- This case suggests that hypokalemia can reveal the Brugada type-1 pattern without changing it, indicating that further research is needed to explore how hypokalemia could influence ventricular arrhythmias beyond just QT interval changes.
Brugada Phenotype Following a Cocaine Overdose.
Cureus
July 2024
Emergency Medicine, ProMedica Monroe Regional Hospital, Monroe, USA.
Brugada syndrome is a rare cardiac condition characterized by distinctive electrocardiogram patterns, predisposing individuals to fatal arrhythmias. While primarily linked to a loss-of-function mutation in the SCN5A gene, acquired forms of the syndrome have been associated with various factors, including drug use. We present a case of a 31-year-old female who presented to the emergency department unresponsive following cocaine use and developed type 1 Brugada ECG patterns alongside an incomplete right bundle branch block in V1-V3, ST elevations with biphasic waves, and diffuse repolarization abnormalities with J point deviations while in the intensive care unit.
View Article and Find Full Text PDFPredicting ventricular arrhythmia inducibility in ajmaline-induced Brugada type I pattern: Validation of the dST-Tiso interval.
J Cardiovasc Electrophysiol
September 2024
Maria Cecilia Hospital, GVM Care & Research, Cotignola, Ravenna, Italy.
Introduction: The dST-Tiso is a newly proposed electrocardiographic (ECG) marker during Brugada (BrS) type I pattern, that predicts the likelihood of ventricular arrhythmia (VA) inducibility in patients with ajmaline-induced pattern. The objective of this study was to validate the effectiveness of this criterion using an independent data set.
Methods: Consecutive patients exhibiting a BrS type I ECG pattern following ajmaline administration underwent programmed ventricular stimulation (PVS).
Brugada syndrome: identification of subjects at risk and therapy.
Eur Heart J Suppl
April 2024
Division of Cardiology, Policlinico Casilino, Rome.
Brugada syndrome mainly affects young subjects with structurally normal heart and can cause x syncope or sudden death due to ventricular arrhythmias, even as the first manifestation, in approximately 5-10% of cases. To date, two questions remain open: how to recognize subjects who will experience arrhythmic events and how to treat them. The guidelines suggest treating subjects with a previous history of cardiac arrest or arrhythmogenic syncope, while they are unconclusive about the management of asymptomatic patients, who represent ∼90% of Brugada patients.
View Article and Find Full Text PDFLong-term follow-up of patients with Brugada syndrome: Foremost risk factors associated with overall arrhythmic events.
Medicine (Baltimore)
May 2024
Department of Cardiology, Private Clinic, Ankara, Turkey.
Brugada syndrome (BS) is characterized by ST segment elevation in right precordial leads (V1-V3), ventricular tachycardia (VT), ventricular fibrillation (VF), and sudden cardiac death (SCD) in individuals without structural heart disease. The aim of this study is to contribute to the controversial issue of finding the most valuable marker that can predict poor prognosis during follow-up in patients with a diagnosis of BS. A total of 68 patients diagnosed with BS or had Brugada-type ECG change between January 1997 and July 2012 at the Department of Cardiology of Başkent University Faculty of Medicine, Ankara, Turkey, were included in this cohort study.
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