Objective: The objective of our study was to determine how well CT predicts the need for laparotomy in hemodynamically stable patients with penetrating abdominal injury.
Materials And Methods: We reviewed MEDLINE articles published from January 1994 through June 2008. The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy were calculated for each source and collectively using a meta-analysis.
Results: Of 180 relevant studies, five were included in the meta-analysis. Pooled weighted estimates of sensitivity, specificity, NPV, PPV, and accuracy were 94.90%, 95.38%, 98.62%, 84.51%, and 94.70%, respectively.
Conclusion: CT in patients with penetrating abdominal trauma has high sensitivity, specificity, NPV, and accuracy, but has lower PPV in determining the need for laparotomy. It follows that CT is an indispensable tool in predicting the need for laparotomy in these patients but still has room for improvement.
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http://dx.doi.org/10.2214/AJR.08.1927 | DOI Listing |
Int J Emerg Med
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Departamento de Cardiología, Fundación Valle del Lili, Carrera 98 No. 18 - 49, Cali, 760032, Colombia.
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View Article and Find Full Text PDFBackground: Drug delivery to the central nervous system has long been hindered by the restrictive properties of the blood-brain barrier (BBB). Recent advances have highlighted the ability of certain antibody "shuttles'' to traverse the BBB and enhance the delivery of diverse therapeutic payloads. However the true potential of this approach remains underexplored and is limited by traditional in vitro screening platforms that fail to capture the complexities of in vivo biology.
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