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Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion.
EMBO J
January 2025
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
Biogenesis of membrane-bound organelles involves the synthesis, remodeling, and degradation of their constituent phospholipids. How these pathways regulate organelle size remains poorly understood. Here we demonstrate that a lipid-degradation pathway inhibits expansion of the endoplasmic reticulum (ER) membrane.
View Article and Find Full Text PDFImproving the Characteristics of Fruiting Bodies in : The Impact of Rolipram-Induced cAMP Modulation.
Metabolites
November 2024
Microbial Research Institute of Liaoning Province, Chaoyang 122000, China.
Strains XG04 and XGT2 of (Berk.) Singer demonstrate a high degree of genomic similarity, with XGT2 representing a systematic selection of XG04 and exhibiting enhanced phenotypic traits. An investigation into the differences between these strains was conducted using untargeted metabolomics to identify potential causal factors.
View Article and Find Full Text PDFImmune drivers of pain resolution and protection.
Nat Immunol
December 2024
F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Immune cells are involved in the pathogenesis of pain by directly activating or sensitizing nociceptor sensory neurons. However, because the immune system also has the capacity to self-regulate through anti-inflammatory mechanisms that drive the resolution of inflammation, it might promote pain resolution and prevention. Here, we describe how immune cell-derived cytokines can act directly on sensory neurons to inhibit pain hypersensitivity and how immune-derived endogenous opioids promote analgesia.
View Article and Find Full Text PDFThe involvement of endogenous melatonin in LPS-induced M1-like macrophages and its underlying synthesis mechanism regulated by IRF3.
Exp Cell Res
November 2024
School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China. Electronic address:
Article Synopsis
- * The study found that the lipopolysaccharide (LPS) treatment, which normally promotes M1 polarization, actually increases endogenous MLT secretion in macrophages, indicating a possible protective mechanism.
- * Results show that LPS activates the TLR4/TRIF pathway leading to MLT secretion, with MLT helping to inhibit M1 polarization and reduce apoptosis in macrophages, highlighting its role in immune response and pathogen clearance.
Galvanin is an electric-field sensor for directed cell migration.
bioRxiv
September 2024
Department of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Article Synopsis
- Directed cell migration is essential for immune responses, especially for neutrophils during tissue injury or infection, which is influenced by electric fields generated by skin disruption.
- A novel protein called Galvanin has been identified as crucial for neutrophils to change migration direction in response to electric fields, based on a CRISPR screen.
- Galvanin quickly moves to one side of the cell when exposed to an electric field, altering how neutrophils extend and retract, indicating it acts as a sensor that guides cell movement in response to electrical stimuli.
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