Tryparedoxin peroxidase (TryP) is a key enzyme of the trypanothione-dependent metabolism for removal of oxidative stress in leishmania. These enzymes function as antioxidants through their peroxidase and peroxynitrite reductase activities. Inhibitors of this enzyme are presumed to be antilesihmania drugs and structural studies are prerequisite of rational drug design. We have constructed three dimensional structure of TryP of Leishmania infantum using comparative modeling. Structural analysis reveals several interesting features. Moreover, it shows remarkable structural difference with human host glutathione peroxidase, an enzyme involved in similar function and TryP from Leishmania major.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/138920109789069305 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
New insights into the pro-oxidant mechanism of dehydroleucodine on Trypanosoma cruzi.
Sci Rep
August 2024
Instituto de Histología y Embriología, IHEM-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo (UNCuyo), 5500, Mendoza, Argentina.
Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is one of the most important neglected diseases in Latin America. The limited use of the current nitro-derivative-based chemotherapy highlights the need for alternative drugs and the identification of their molecular targets.
View Article and Find Full Text PDFTrypanosoma cruzi interaction with host tissues modulate the composition of large extracellular vesicles.
Sci Rep
February 2024
EVAHPI Research Group, Laboratório de Biologia Celular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, Paraná, Brazil.
Trypanosoma cruzi is the protozoan that causes Chagas disease (CD), an endemic parasitosis in Latin America distributed around the globe. If CD is not treated in acute phase, the parasite remains silent for years in the host's tissues in a chronic form, which may progress to cardiac, digestive or neurological manifestations. Recently, studies indicated that the gastrointestinal tract represents an important reservoir for T.
View Article and Find Full Text PDFThe SET7 protein of Leishmania donovani moderates the parasite's response to a hostile oxidative environment.
J Biol Chem
March 2024
Department of Microbiology, University of Delhi South Campus, New Delhi, India. Electronic address:
SET domain proteins methylate specific lysines on proteins, triggering stimulation or repression of downstream processes. Twenty-nine SET domain proteins have been identified in Leishmania donovani through sequence annotations. This study initiates the first investigation into these proteins.
View Article and Find Full Text PDFParacrine Signaling Mediated by the Cytosolic Tryparedoxin Peroxidase of .
Pathogens
January 2024
Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11000, Uruguay.
Peroxiredoxins are abundant and ubiquitous proteins that participate in different cellular functions, such as oxidant detoxification, protein folding, and intracellular signaling. Under different cellular conditions, peroxiredoxins can be secreted by different parasites, promoting the induction of immune responses in hosts. In this work, we demonstrated that the cytosolic tryparedoxin peroxidase of (cTXNPx) is secreted by epimastigotes and trypomastigotes associated with extracellular vesicles and also as a vesicle-free protein.
View Article and Find Full Text PDFSynthesis and evaluation of hybrid sulfonamide-chalcones with potential antileishmanial activity.
Arch Pharm (Weinheim)
March 2024
Laboratório de Catalise Orgânica, Instituto de Pesquisa de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Leishmaniasis is an emerging tropical infectious disease caused by a protozoan parasite of the genus Leishmania. In this work, the molecular hybridization between a trimethoxy chalcone and a sulfonamide group was used to generate a series of sulfonamide-chalcones. A series of eight sulfonamide-chalcone hybrids were made with good yields (up to 95%).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!