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Feasibility of Measuring Context Specific Sedentary Behavior and Pulse Wave Velocity in Endometrial Cancer Survivors.
Integr Cancer Ther
March 2025
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Purpose: Sedentary behavior (SB) contributes to the heightened risk of cardiovascular disease (CVD) in endometrial cancer survivors (ECS). This feasibility study aimed to evaluate key outcomes to assess the practicality of SB reduction interventions for ECS. Secondary aims included SB domain assessment and preliminary efficacy testing of the relationship between SB and arterial stiffness.
View Article and Find Full Text PDFMedication Adherence of Children with Congenital Hypothyroidism in Iran: A National Cross-Sectional Study.
Int J Endocrinol Metab
April 2024
Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Background: Congenital hypothyroidism is the most common preventable and treatable cause of intellectual disability in children. A key component of the surveillance system for congenital hypothyroidism is ensuring a regular treatment program for affected children. Despite nearly 20 years since the successful implementation of the newborn screening program for hypothyroidism in Iran, a comprehensive evaluation of patients' adherence to treatment has not been conducted.
View Article and Find Full Text PDFPatients' Perceptions and Experiences With Outpatient Hip and Knee Arthroplasty: A Qualitative Study.
Cureus
February 2025
Department of Quality Improvement, Zuyderland Medical Center, Heerlen, NLD.
Background Outpatient joint arthroplasty (OJA) of the hip and knee is becoming increasingly popular within the orthopedic community. Most evidence regarding the safety and feasibility of OJA has been gathered from the perspectives of surgeons and healthcare organizations. However, the success of these pathways also hinges on patients feeling safe and adequately prepared to return home.
View Article and Find Full Text PDFOutreach by Municipal Public Health Nurses to Vulnerable Pregnant Women During the COVID-19 Pandemic: A Qualitative Study.
Cureus
February 2025
Research Institute of Nursing Care for People and Community, University of Hyogo, Akashi, JPN.
Background: The coronavirus disease 2019 (COVID-19) pandemic posed substantial challenges for public health nurses (PHNs) in delivering outreach services to vulnerable pregnant women and families requiring assistance. Despite restrictive measures, the importance of maintaining face-to-face support and implementing adaptive strategies was evident.
Objectives: This study aimed to identify the key characteristics of outreach practices conducted by PHNs during the pandemic, the challenges they encountered, and the strategies needed to address these issues effectively.
Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis.
Epigenetics Chromatin
March 2025
State Key Laboratory of Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Organ Fibrosis, Pingyuan Laboratory, College of Life Science, Henan Normal University, 46 Jianshe Road, Xinxiang, Henan, 453007, China.
Background: Pulmonary fibrosis is a relentless and ultimately fatal lung disorder. Despite a wealth of research, the intricate molecular pathways that contribute to the onset of PF, especially the aspects related to epigenetic modifications and chromatin dynamics, continue to be elusive and not fully understood.
Methods: Utilizing a bleomycin-induced pulmonary fibrosis model, we conducted a comprehensive analysis of the interplay between chromatin structure, chromatin accessibility, gene expression patterns, and cellular heterogeneity.
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