A problem common to biology and economics is the transfer of resources from parents to children. We consider the issue under the assumption that the number of offspring is unknown and can be represented as a random variable. There are 3 basic assumptions. The first assumption is that a given body of resources can be divided into consumption (yielding satisfaction) and transfer to children. The second assumption is that the parents' welfare includes a concern for the welfare of their children; this is recursive in the sense that the children's welfares include concern for their children and so forth. However, the welfare of a child from a given consumption is counted somewhat differently (generally less) than that of the parent (the welfare of a child is "discounted"). The third assumption is that resources transferred may grow (or decline). In economic language, investment, including that in education or nutrition, is productive. Under suitable restrictions, precise formulas for the resulting allocation of resources are found, demonstrating that, depending on the shape of the utility curve, uncertainty regarding the number of offspring may or may not favor increased consumption. The results imply that wealth (stock of resources) will ultimately have a log-normal distribution.
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http://dx.doi.org/10.1073/pnas.0905613106 | DOI Listing |
J Neurochem
January 2025
Nantes Université, INRAE, UMR 1280, Physiologie des Adaptations Nutritionnelles, Nantes, France.
Obesity leads to a number of health problems, including learning and memory deficits that can be passed on to the offspring via a developmental programming process. However, the mechanisms involved in the deleterious effects of obesity on cognition remain largely unknown. This study aimed to assess the impact of obesity on the production of sphingolipids (ceramides and sphingomyelins) in the brain and its relationship with the learning deficits displayed by obese individuals.
View Article and Find Full Text PDFHum Reprod Open
December 2024
Vrije Universiteit Brussel (VUB), Brussels Health Campus/Faculty of Medicine and Pharmacy, Research Group Genetics, Reproduction and Development , Laarbeeklaan 103, 1090 Brussels, Belgium.
Study Question: Is there an association between different mitochondrial DNA (mtDNA) genotypes and female infertility or ovarian response, and is the appearance of variants in the oocytes favored by medically assisted reproduction (MAR) techniques?
Summary Answer: Ovarian response was negatively associated with global non-synonymous protein-coding homoplasmic variants but positively associated with haplogroup K; the number of oocytes retrieved in a cycle correlates with the number of heteroplasmic variants in the oocytes, principally with variants located in the hypervariable (HV) region and rRNA loci, as well as non-synonymous protein-coding variants.
What Is Known Already: Several genes have been shown to be positively associated with infertility, and there is growing concern that MAR may facilitate the transmission of these harmful variants to offspring, thereby passing on infertility. The potential role of mtDNA variants in these two perspectives remains poorly understood.
J Hazard Mater
January 2025
Department of Marine Ecology, College of Marine Life Sciences, Ocean University of China, No.5 Yushan Road, Qingdao, China; Laboratory for Marine Ecology and Environmental Science, Qingdao Marine Science and Technology Center, Qingdao, China. Electronic address:
The emerging contaminants hexabromocyclododecanes (HBCDs) are proved to exhibit highly reproductive toxicity to marine rotifer Brachionus plicatilis, but how about the toxic differentiation among three diastereoisomers of HBCD, and what's the possible hidden mechanism? B. plicatilis was exposed to different concentrations of HBCD diastereoisomers, and the results showed that α-, β- and γ-HBCD exhibited various toxicity on it, the adverse effects on individual life history traits included shortened lifespan, shortened body length and reduced offspring number. Population dynamics analysis showed that the maximum population density and time to reach it were also significantly influenced.
View Article and Find Full Text PDFEndocrinology
January 2025
Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, UT, USA.
We created the c.1286C>G stop-gain mutation found in a family with primary ovarian insufficiency (POI) at age 30 years. The Eif4enif1 C57/Bl6 transgenic mouse model contained a floxed exon 10-19 cassette with a conditional knock-in cassette containing the c.
View Article and Find Full Text PDFClin Med (Lond)
January 2025
Department of Applied Health, School of Health Sciences, Murray Learning Centre, College of Medicine and Health, University of Birmingham, Birmingham B15 2FG, UK. Electronic address:
Adequate control of thyroid function is crucial for optimal pregnancy outcomes and neurodevelopment of the offspring and testing for thyroid function is ideally performed using manufacturer and gestation specific reference ranges. Whilst universal screening for thyroid dysfunction is not recommended, targeted case finding of women at risk of thyroid disease during pregnancy is advised. A number of controversies continue to fuel debate including: (i) the target range for thyroid stimulating hormone (TSH) in women with subfertility planning pregnancy (ii) management of mild thyroid hypofunction before and during pregnancy (iii) the treatment of TPO-antibody positive euthyroid women with levothyroxine (iv) the optimal choice of antithyroid treatment in women with hyperthyroidism.
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