Isoprenoids are essential for fruiting body formation in Myxococcus xanthus.

J Bacteriol

Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Biozentrum/Campus Riedberg, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Published: September 2009

It was recently shown that Myxococcus xanthus harbors an alternative and reversible biosynthetic pathway to isovaleryl coenzyme A (CoA) branching from 3-hydroxy-3-methylglutaryl-CoA. Analyses of various mutants in these pathways for fatty acid profiles and fruiting body formation revealed for the first time the importance of isoprenoids for myxobacterial development.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737962PMC
http://dx.doi.org/10.1128/JB.00539-09DOI Listing

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