Optimization of kinase selectivity for a set of benzothiophene MK2 inhibitors provided analogs with potencies of less than 500 nM in a cell based assay. The selectivity of the inhibitors can be rationalized by examination of X-ray crystal structures of inhibitors bound to MK2.
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Department of Hematology, Shaoxing Shangyu people's Hospital, Shaoxing, People's Republic of China.
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