AI Article Synopsis
- Urinary tract infections (UTIs) are a major cause of serious bacterial infections in young kids, often linked to vesicoureteral reflux (VUR), a common condition in pediatric urology that increases the risk of UTIs and can lead to kidney damage.
- The interplay between bacterial factors and the body's defense system contributes to kidney harm, while some issues related to VUR aren't caused by infections.
- Effective treatment for VUR and UTIs is debated due to a lack of solid research, but the new RIVUR study aims to clarify the benefits of using antibiotics to prevent UTIs in children with VUR.*
Article Abstract
Urinary tract infection (UTI) is a leading cause of serious bacterial infection in young children. Vesicoureteral reflux (VUR), a common pediatric urologic disorder, is believed to predispose to UTI, and both are associated with renal scarring. The complex interaction of bacterial virulence factors and host defense mechanisms influence renal damage. However, some renal parenchymal abnormalities associated with VUR are noninfectious in origin. Long-term, renal parenchymal injury may be associated with hypertension, pregnancy complications, proteinuria, and renal insufficiency. Optimal management of VUR and UTI is controversial because of the paucity of appropriate randomized controlled trials; there is a need for well-designed studies. The recently launched Randomized Intervention for children with VesicoUreteral Reflux (RIVUR) study hopefully will provide insight into the role of antimicrobial prophylaxis of UTI in children with VUR.
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| http://dx.doi.org/10.1016/j.semnephrol.2009.03.011 | DOI Listing |
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