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Favorable inhibitory effect of clodronate on hepatic steatosis in short bowel syndrome model rats.
Pediatr Surg Int
November 2024
Department of Pediatric Surgery, Medical and Dental Area, Research and Education Assembly, Research Field in Medical and Health Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Article Synopsis
- This study looked at how clodronate, which affects vesicular nucleotide transport, impacts liver inflammation linked to intestinal failure in rats with short bowel syndrome.
- The researchers used a rat model that involved feeding them through a vein and surgically removing most of their small intestine, then giving them different doses of clodronate.
- Results showed that high doses of clodronate reduced liver fat and inflammation in the rats, suggesting potential benefits for patients with similar conditions related to intestinal failure.
Size of lipid emulsion droplets influences metabolism in human CD4 T cells.
Biochem Biophys Res Commun
November 2024
Division of Clinical Chemistry and Biochemistry, Children's Research Center, University Children's Hospital Zurich and University of Zurich, Zurich, Switzerland; Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address:
Scope: Triglyceride-based lipid emulsions are critical for total parenteral nutrition (TPN), but their long-term use has adverse effects, such as severe liver dysfunction necessitating improved formulations. This study compares the uptake mechanism and intracellular fate of novel glycerol-stabilized nano-sized lipid emulsions with conventional emulsions in CD4 T cells, focusing on their impact on cellular metabolism.
Methods And Results: Nanoemulsions were formulated with increased glycerol content.
Feeding Parenteral Nutrition in the Neonatal Period Programs Dyslipidemia in Adulthood in Yucatan Miniature Pigs.
J Nutr
November 2024
Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada. Electronic address:
Background: Early nutritional challenges can lead to permanent metabolic changes, increasing risk of developing chronic diseases later in life. Total parenteral nutrition (TPN) is a life-saving nutrition regimen, used especially in intrauterine growth-restricted (IUGR) neonates. Early TPN feeding alters metabolism, but whether these alterations are permanent is unclear.
View Article and Find Full Text PDFA novel nutritional approach to infants and children with congenital diarrhea due to homozygous DGAT1 mutations.
J Pediatr Gastroenterol Nutr
August 2024
Mass General Hospital for Children, Pediatric Gastroenterology, Boston, Massachusetts, USA.
Article Synopsis
- DGAT1 deficiency leads to serious health issues in infants, such as diarrhea and protein-losing enteropathy, making dietary management critical for treatment.
- A study from 2014 to 2020 involved 12 infants with this condition, resulting in new dietary recommendations that focus on an ultralow fat formula combined with lipid infusions.
- The findings suggest that with proper nutritional management, infants can avoid total parenteral nutrition (TPN), improving their growth, development, and overall health while effectively addressing their symptoms.
Evidence and Perspectives for Choline Supplementation during Parenteral Nutrition-A Narrative Review.
Nutrients
June 2024
Department of Neonatology, University Children's Hospital, 72076 Tübingen, Germany.
Choline is an essential nutrient, with high requirements during fetal and postnatal growth. Tissue concentrations of total choline are tightly regulated, requiring an increase in its pool size proportional to growth. Phosphatidylcholine and sphingomyelin, containing a choline headgroup, are constitutive membrane phospholipids, accounting for >85% of total choline, indicating that choline requirements are particularly high during growth.
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