AI Article Synopsis
- Disseminated fungal infections pose a significant risk of death for immunocompromised bone marrow transplant patients, particularly from molds like Scopulariopsis.
- A case is presented involving a 56-year-old man with chronic myelogenous leukemia who developed a fatal Scopulariopsis infection that mimicked other serious fungal infections like Aspergillus and Fusarium.
- Accurate identification of Scopulariopsis through tissue culture is essential for treatment, as these infections are hard to treat and have a high mortality rate among BMT patients.
Article Abstract
Disseminated fungal infections are a major cause of mortality in severely immunocompromised bone marrow transplant (BMT) patients. Scopulariopsis is a soil saprophytic mould that is typically associated with onychomycosis and only rarely associated with disseminated infection with cutaneous findings. We describe a case of fatal disseminated Scopulariopsis infection in a 56-year-old neutropenic male with chronic myelogenous leukemia status post peripheral blood stem cell transplant that was clinically and histologically indistinguishable from disseminated Aspergillus, Fusarium or zygomycosis infection. Distinguishing the above listed fungi by tissue culture is crucial because disseminated Scopulariopsis is difficult to eradicate and associated with a high mortality rate in the immunocompromised BMT patient population.
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| http://dx.doi.org/10.1111/j.1600-0560.2009.01358.x | DOI Listing |
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