Serum lipid peroxides (LPX) were determined in 24 patients with multiple sclerosis and in 30 healthy controls. Patients with relapses or chronic progression had significantly higher serum LPX level than healthy controls: mean 3.09 +/- 0.15 nmol/ml versus 2.30 nmol/ml, p less than 0.01. Relapsing-remitting patients showed slightly higher LPX level than slowly progressive patients. It is supposed that lipid peroxides are unspecific mediators of the inflammatory reaction in multiple sclerosis.
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