In the Republic of Croatia, the perinatal mortality, as an indicator of perinatal care, has decreased from 38.6% in 1950-54 to 10.9% in 1989 which means that today it is on the low mortality level like in the Middle- and West-European countries. The decline of perinatal mortality is especially evident after 1985. There are pronounced differences within the different regions of the Republic of Croatia, the lowest perinatal mortality is in the town of Zagreb and in the central Croatia, while the highest one in the region of Bjelovar, Slavonia and Dalmatia. Comparing the data from 29 maternity hospitals and taking into account a decrease in the number of hospitals with high perinatal mortality (48% in 1972 to zero in 1990) and an increase in the number of hospitals with low mortality (11 or 38% with mortality less than 10% in 1990), an increase of the delivery frequency completed by cesarean section was found: in 1990 there were 31% of the maternity hospitals with more than 10%, 45% with 6-10% and 24% with less than 6% of cesarean sections. Over recent years the maternity hospitals are better supplied with the necessary medical equipment: in 1990 97% of the hospitals were provided with cardiotocographs, 97% with ultrasound apparatuses and 90% with baby incubators. A sufficient number of specialists in gynecology and obstetrics is available, while there are lacking 21 specialists in pediatrics--neonatology, what is one third of the required number.(ABSTRACT TRUNCATED AT 250 WORDS)
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J Womens Health (Larchmt)
January 2025
ICES, Toronto, Canada.
Chronic physical conditions (CPC) and alcohol and substance use disorders (SUD) frequently co-occur, but this has not been examined perinatally. We explored the combined effects of CPC and prepregnancy SUD on perinatal SUD-related adverse events and outpatient care. This population-based study comprised 77,474 people with and 664,751 without CPC with a birth in Ontario, Canada, 2013-2020.
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January 2025
The Morris Kahn Laboratory of Human Genetics, Faculty of Health Sciences Ben Gurion University Beer-Sheva Israel.
The tightly-regulated spatial and temporal distribution of zinc ion concentrations within cellular compartments is controlled by two groups of Zn transporters: the 14-member ZIP/SLC39 family, facilitating Zn influx into the cytoplasm from the extracellular space or intracellular organelles; and the 10-member ZnT/SLC30 family, mobilizing Zn in the opposite direction. Genetic aberrations in most zinc transporters cause human syndromes. Notably, previous studies demonstrated osteopenia and male-specific cardiac death in mice lacking the ZnT5/ zinc transporter, and suggested association of two homozygous frameshift variants with perinatal mortality in humans, due to hydrops fetalis and hypertrophic cardiomyopathy.
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January 2025
Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL, 32610, USA.
Background: Cows that develop metritis experience dysbiosis of their uterine microbiome, where opportunistic pathogens overtake uterine commensals. An effective immune response is critical for maintaining uterine health. Nonetheless, periparturient cows experience immune dysregulation, which seems to be intensified by prepartum over-condition.
View Article and Find Full Text PDFBMJ Open
January 2025
Centre for Primary Care and Public Health, Queen Mary University of London Wolfson Institute of Preventive Medicine, London, UK.
Objective: In the UK and worldwide, there are substantial ethnic inequalities in maternal and perinatal care and outcomes. We aim to assess the impact of the unprecedented change in care provision during the COVID-19 pandemic on inequalities in adverse maternity outcomes.
Design: Retrospective cohort study using structured electronic health record data.
Am J Perinatol
January 2025
Ob-gyn, University of Minnesota System, Minneapolis, United States.
Background: Obesity is associated with an increased risk of stillbirth and neonatal death. Since the publication of A Randomized Trial of Induction Versus Expectant Management (ARRIVE) in 2018, there was an increase in 39 weeks deliveries. The objective of this study was to evaluate the trends in perinatal mortality by BMI category from 2015 to 2020.
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