This is the case of a 63 years old female that was admitted with abdominal pain mainly localized in the left lower quadrant, with diffuse radiation to the rest of the abdomen. It persisted for two days and worsened on the day of admission. It was associated with two episodes of vomiting and fever. She had no urinary symptoms or lumbar zone tenderness. There was no familial history of dextrocardia. The physical examination showed discrete abdominal distention; bowel movements diminished in the left lower quadrant with guarding and rebound tenderness at this site. The reminder of the physical examination was normal. The ECG findings in Lead I: P, QRS and T waves inverted or upside down. Lead II: represented the usual lead III and vice versa. AVR and AVL were reversed and prominent negative deflections were seen in AVL rather than in AVR. AVF was unaffected. The V1-V6 complexes showed decreasing amplitude. V1 was the equivalent of the usual V2 and vice versa. The differential diagnosis included dextroposition of the heart, dextroversion of the heart and misplaced electrodes. The chest X-Ray findings were consistent with dextrocardia. Abdominal and pelvic CT showed situs inversus, inflammatory process at the cecum and proximal ascending colon located on the left side of the abdomen, compatible with perforated appendicitis. No abscess or free intraperitoneal air was seen. The patient was started on empiric antibiotic coverage with cleocin and cipro. Surgical intervention was performed with the findings of a perforated and gangrenous appendix and severe inflammation at the left side of the abdomen. The surgical wound was closed by second intention 3 days later without complications. The patient recovered and was discharged home to continue with oral antibiotic therapy. The incidence of dextrocardia with situs inversus is 1:5,000 to 1:10,000. A review of the American medical literature from 1965 to the present revealed only 18 acute presentations of situs inversus with the following distribution: appendix (4 cases), trauma (4 cases), cardiovascular (3 cases), gastrointestinal (3 cases), gallbladder (3 cases), spleen (1 case). The case presented is a typical "after-the-facts-findings" were the initial evaluation overlooked a typical presentation, just side-reversed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

situs inversus
12
dextrocardia situs
8
left lower
8
lower quadrant
8
physical examination
8
vice versa
8
left side
8
side abdomen
8
cases
5
acute abdominal
4

Similar Publications

Kartagener syndrome (KS) is a rare congenital disorder, characterized by sinusitis, bronchiectasis and situs inversus. Lung transplantation is an effective treatment for end-stage lung failure, but dextrocardia and differences between hilar structures and pulmonary lobes require adjustments to conventional surgical technique. We present a case of a double-lung transplant without extracorporeal oxygenation in a 48-year-old male patient with KS.

View Article and Find Full Text PDF

Kartagener syndrome is a rare ciliopathic genetic disorder characterized by a triad of chronic sinusitis, situs inversus, and bronchiectasis. The underlying pathophysiology involves reduced ciliary motility due to defects in ciliary structure and function within the respiratory tract and fallopian tubes. Diagnosis is typically confirmed through imaging studies such as X-rays, CT scans, and echocardiograms, which reveal the abnormal orientation of the heart and other organs.

View Article and Find Full Text PDF

Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder requiring airway clearance techniques for mucus removal. We aimed to evaluate the feasibility and the effect of the active cycle of breathing technique (ACBT) versus oscillating positive expiratory pressure therapy (OPEP) in improving lung function and functional exercise capacity among children with PCD in Palestine. 32 PCD children (6-18 years) were included in a 12-week home-based feasibility study.

View Article and Find Full Text PDF

"Situs inversus with levocardia" refers to the mirror-image lateral orientation of the abdominal organs with a normally oriented, left-sided heart. This anatomical anomaly arises from abnormalities in the biochemical signaling systems mediating embryological development. We present a case of situs inversus with levocardia incidentally discovered in a healthy 24-year-old male during workup following a motor vehicle collision.

View Article and Find Full Text PDF

Regulation of INPP5E in Ciliogenesis, Development, and Disease.

Int J Biol Sci

January 2025

Department of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA.

Inositol polyphosphate-5-phosphatase E (INPP5E) is a 5-phosphatase critically involved in diverse physiological processes, including embryonic development, neurological function, immune regulation, hemopoietic cell dynamics, and macrophage proliferation, differentiation, and phagocytosis. Mutations in cause Joubert and Meckel-Gruber syndromes in humans; these are characterized by brain malformations, microphthalmia, situs inversus, skeletal abnormalities, and polydactyly. Recent studies have demonstrated the key role of INPP5E in governing intracellular processes like endocytosis, exocytosis, vesicular trafficking, and membrane dynamics.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!