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New proposal for the systematic nomenclature of scorpion peptides.
Toxicon
January 2025
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, 62210, Morelos, Mexico. Electronic address:
The systematic annotation of novel peptides found in the venom of scorpions needs revision. The commonly used two-letter acronym with the initials of the genus and the species is not discriminative and induces confusion. A new universal five-letter abbreviated code is here proposed.
View Article and Find Full Text PDFUsing IMGT unique numbering for IG allotypes and Fc-engineered variants of effector properties and half-life of therapeutic antibodies.
Immunol Rev
November 2024
IMGT®, the international ImMunoGeneTics information system® (IMGT), Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UMR 9002 Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), Montpellier Cedex 5, France.
Article Synopsis
- Therapeutic monoclonal antibodies (mAbs) are primarily of the IgG1, IgG2, and IgG4 classes, and their effectiveness can be enhanced by modifying heavy chains for improved immune responses and longer half-life.
- Allotypes and Fc-engineered variants of these antibodies are classified using a specific nomenclature (IMGT/HGNC) that designates their species and modifications based on amino acid variations.
- In total, 126 variants are identified, each characterized by specific motifs that relate to their functions, such as effector capabilities and half-life, aiding in their classification and therapeutic applications.
MilkOligoThesaurus, a dataset of mammalian milk oligosaccharide synonyms.
Data Brief
June 2024
GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet-Tolosan, France.
There is a growing interest in milk oligosaccharides (MOs) because of their numerous benefits for newborns' and long-term health. A large number of MO structures have been identified in mammalian milk. Mostly described in human milk, the oligosaccharide richness, although less broad, has also been reported for a wide range of mammalian species.
View Article and Find Full Text PDFMultiple reaction monitoring (MRM) profiling is a strategy for the exploratory analysis of small molecules and lipids by direct sample injection, ie, without the use of chromatographic separation. It is based on instrument methods that comprise a list of ion transitions (MRMs), in which the precursor ion is the expected ionized of the lipid at its species level, ie, the description of lipid class and number of carbon and double bonds in the fatty acid chain(s), and the product ion is a fragment expected for the lipid class or for the fatty acid neutral loss. The Lipid Maps database is expanding constantly, and therefore the MRM-profiling methods associated with this database need to be continuously updated.
View Article and Find Full Text PDFToward Diverse or Standardized: A Systematic Review Identifying Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve in Nomenclature.
Neuromodulation
April 2022
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:
Objectives: After 20 years of development, there is confusion in the nomenclature of transcutaneous stimulation of the auricular branch of the vagus nerve (ABVN). We performed a systematic review of transcutaneous stimulation of ABVN in nomenclature.
Materials And Methods: A systematic search of the literature was carried out, using the bibliographic search engine PubMed.
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