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http://dx.doi.org/10.1258/jrsm.2009.s19004 | DOI Listing |
Nurs Educ Perspect
October 2024
About the Authors Judith Bacchus Cornelius, PhD, RN, FAAN, ANEF, is a professor, College of Health and Human Services, University of North Carolina at Charlotte, Charlotte, North Carolina. Charlene Downing, PhD, RN, is a professor, Department of Nursing, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa. Adesola A. Ogunfowokan, PhD, RN, FWACN, is a professor, Community Health Nursing, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria. Nompumelelo Ntshingila, DCur(UJ), is an associate professor, Department of Nursing, Faculty of Health Sciences, University of Johannesburg. Florence Okoro, PhD, RN, is an associate professor, College of Health and Human Services, University of North Carolina at Charlotte. Ijeoma Enweana, DNP, RN, CVN, is adjunct nursing faculty, Presbyterian School of Nursing, Queens University of Charlotte, Charlotte, North Carolina. Oluwayemisi Olagunju, PhD, is senior lecturer, Department of Nursing Science, Obafemi Awolowo University. Funding was received from the University of North Carolina at Charlotte Global Learning and Internationalization Institute. For more information, contact Dr. Cornelius at
The COVID-19 pandemic presented opportunities for educational innovations and the development of intercultural learning experiences. A global health assignment guided by a collaborative online international learning pedagogy was assigned to doctoral nursing students from three different countries. Icebreaker activities, along with the Culturally You diagram, commenced the team-building process.
View Article and Find Full Text PDFSci Rep
December 2024
Theoretical Ecology and Engineering Ecology Research Group, School of Life Sciences, Shandong University, Qingdao, Shandong, China.
Temperature and nutrients are known as crucial drivers for the variations of bacterial community structure and functions in oceans and lakes. However, their significance and mechanisms in influencing the bacterial community structure and function in mountain stream remain unclear. In this study, we investigated the spatiotemporal patterns of the bacterial communities and the main environmental factors in the Taizicheng River, a high-latitude mountainous stream, to reveal the main driving factors for sedimental bacterial communities.
View Article and Find Full Text PDFTrends Cancer
December 2024
Charité - Universitätsmedizin Berlin, Institute of Pathology, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
In 1982, the RAS genes HRAS and KRAS were discovered as the first human cancer genes, with KRAS later identified as one of the most frequently mutated oncogenes. Yet, it took nearly 40 years to develop clinically effective inhibitors for RAS-mutant cancers. The discovery in 2013 by Shokat and colleagues of a druggable pocket in KRAS paved the way to FDA approval of the first covalently binding KRAS inhibitors, sotorasib and adagrasib, in 2021 and 2022, respectively.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Introduction: Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.
Methods: Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging.
Mech Ageing Dev
December 2024
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, 79430, TX, USA; Nutritional Sciences Department, College Human Sciences, Texas Tech University, Lubbock, TX 79409; Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Speech, Language, and Hearing Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address:
Chronic sleep deprivation and lack of physical exercise may have detrimental effects on overall health, particularly in terms of brain health, with significant implications for cognitive function and well-being. This review explores the impact of chronic sleep deprivation and physical exercise on brain atrophy in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Drawing insights from 40 selected studies, the review synthesizes evidence on these lifestyle factors' correlations with neurodegenerative changes.
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