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β-Carotene Impacts the Liver MicroRNA Profile in a Sex-Specific Manner in Mouse Offspring of Western Diet-Fed Mothers: Results from Microarray Analysis by Direct Hybridization.
Int J Mol Sci
November 2024
Galascreen Laboratories, University of Calabria, 87036 Rende, Italy.
Maternal unbalanced diets cause adverse metabolic programming and affect the offspring's liver microRNA (miRNA) profile. The liver is a site of β-carotene (BC) metabolism and a target of BC action. We studied the interaction of maternal Western diet (WD) and early-life BC supplementation on the epigenetic remodeling of offspring's liver microRNAs.
View Article and Find Full Text PDFComprehensive characterization of nutritional components in sweetpotato (Ipomoea batatas [L]. Lam.) during long-term post-harvest storage.
J Plant Physiol
December 2024
Key Laboratory of Sweetpotato Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, Xuzhou Institute of Agricultural Sciences in Jiangsu Xuhuai District, Xuzhou, 221131, Jiangsu Province, China; School of Life Sciences, Jiangsu Normal University, Xuzhou, 22111, Jiangsu Province, China. Electronic address:
To uncover the variation patterns of the nutritional components in sweetpotato storage roots during long-term storage comprehensively, the general nutrients, phytochemicals, and starch properties of nine sweetpotato varieties with different flesh colors were quantified and analyzed by chemical and physical techniques. During the storage, the starch content decreased firstly and then increased, with sugar content the opposite. The crude protein content and the total dietary fiber content both increased continuously.
View Article and Find Full Text PDFA hyaluronic acid-modified cyclodextrin self-assembly system for the delivery of β-carotene in the treatment of dry eye disease.
Int J Biol Macromol
December 2024
Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Dry eye disease (DED) is a multifactorial ocular disease, the core mechanism of which is the tear film instability caused by ocular oxidative stress damage and inflammation. Although various pharmaceutical agents are available for DED treatment, their effectiveness is often limited by the eyes' unique biological barriers, and the long-term use of steroid hormones can lead to several adverse effects. This study reported a nano-supramolecular delivery system consisting of a polycyclodextrin (PCD), hyaluronic acid (HA) and the natural compound β-carotene (BC) for the DED treatment.
View Article and Find Full Text PDFIntegrating Radioprotective Agents into Post-Mastectomy Radiotherapy: Optimization of Reconstructive Outcomes in Breast Cancer.
J Surg Res (Houst)
October 2024
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California, USA.
Surgical intervention utilizing various approaches is a cornerstone in the management of breast cancer. The surgical approaches include lumpectomy, mastectomy, axillary lymph node dissection, and primary or delayed reconstruction. Post-mastectomy radiotherapy is frequently recommended in cases of advanced tumors and extensive lymph node involvement.
View Article and Find Full Text PDFSustainable Recovery of Polyphenols and Carotenoids from Horned Melon Peel via Cloud Point Extraction.
Foods
September 2024
Faculty of Technology Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.
Using natural plant extracts as food additives is a promising approach for improving food products' quality, nutritional value, and safety, offering advantages for both consumers and the environment. Therefore, the main goal of this study was to develop a sustainable method for extracting polyphenols and carotenoids from horned melon peel using the cloud point extraction (CPE) technique, intending to utilize it as a natural food additive. CPE is novel promising extraction method for separation and pre-concentration of different compounds while being simple, inexpensive, and low-toxic.
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