Opiate antagonists suppress ACTH(1-24)-induced excessive grooming in the rat.

Neurosci Lett

Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, Institute of Molecular Biology, Padualaan 8, Utrecht, The Netherlands.

Published: May 1976

Intraventricular injection of ACTH(1-24) in rats induces excessive grooming behavior, and subsequent peripheral administration of specific opiate antagonists suppresses this peptide-induced grooming response. Intraventricular injection of morphine mimics both in intact and hypophysectomized rats' - to a certain extent - peptide-induced grooming. The results suggest similarities in the interaction of morphine and ACTH(1-24) with central nervous structures.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0304-3940(76)90008-2DOI Listing

Publication Analysis

Top Keywords

opiate antagonists
8
excessive grooming
8
intraventricular injection
8
peptide-induced grooming
8
antagonists suppress
4
suppress acth1-24-induced
4
acth1-24-induced excessive
4
grooming
4
grooming rat
4
rat intraventricular
4

Similar Publications

Neuropeptide FF (NPFF) is an endogenous octapeptide that was originally isolated from the bovine brain. It belongs to the RFamide family of peptides that has a wide range of physiological functions and pathophysiological effects. NPFF and its receptors, NPFFR1 and NPFFR2, abundantly expressed in rodent and human brains, participate in cardiovascular regulation.

View Article and Find Full Text PDF

Buprenorphine and postpartum contraception utilization among people with opioid use disorder: a multi-state analysis.

Addict Sci Clin Pract

January 2025

Departments of Family and Community Medicine and Health and Clinical Outcomes Research, Saint Louis University School of Medicine, Saint Louis, MO, USA.

Background: The postpartum period provides an opportunity for birthing people with opioid use disorder (OUD) to consider their future reproductive health goals. However, the relationship between the use of medication for opioid use disorder (MOUD) and contraception utilization is not well understood. We used multistate administrative claims data to compare contraception utilization rates among postpartum people with OUD initiating buprenorphine (BUP) versus no medication (psychosocial services receipt without MOUD (PSY)) in the United States (US).

View Article and Find Full Text PDF

Effect of buprenorphine delivered by target-controlled infusion on the minimum alveolar concentration of isoflurane in cats.

Vet Anaesth Analg

January 2025

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.

Objective: To characterize the effect of buprenorphine on the minimum alveolar concentration of isoflurane (MACiso) in cats.

Study Design: Randomized, crossover, experimental study.

Animals: A group of six healthy male neutered cats, aged 2-8 years with body mass 5.

View Article and Find Full Text PDF

Children are highly sensitive to toxins which can damage their organs and lead to death. Investigating the main causes of intoxication could reduce mortality and morbidity in children. In this cross-sectional study, the documents of all poisoned patients (214 cases) admitted to the emergency department of Taleghani children`s Hospital between April 2020 and 2023 were investigated.

View Article and Find Full Text PDF

Background: Xylazine is a α2-adrenergic receptor agonist, used for sedation in veterinary contexts. Although it is increasingly found in overdose deaths across North America, the clinical management of xylazine-involved overdoses has not been extensively studied, especially in community-based harm reduction settings. Here we present a clinical series of xylazine-involved overdose and share the clinical approach and lessons learned by a community overdose response team in Tijuana, Mexico amidst the arrival of xylazine.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!