Acantholytic dyskeratotic acanthomas of the skin have been recently described in several publications. They differ from acantholytic acanthomas by the presence of dyskeratosis. However these tumors have never been described in nails. We report three cases localized on the thumb nail.
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Acantholytic Dyskeratotic Acanthoma of the Nail Revealed by a Longitudinal Erythronychia.
Skin Appendage Disord
December 2024
Dermatology Department, Habib Thameur Hospital, "Genodermatoses and Cancers LR12SP03", Tunis, Tunisia.
Introduction: Focal acantholytic dyskeratosis is a distinctive histological pattern first described by Ackerman in 1972, consisting of focal suprabasal clefts in the epidermis and dyskeratotic cells at all levels of the epidermis with hyperkeratosis and parakeratosis. The first case of subungual acantholytic dyskeratosis acanthoma (ADA) was reported in 1990. This subungual variant is a very rare entity.
View Article and Find Full Text PDFSubungual Acantholytic Dyskeratotic Acanthoma: A Case Report and Literature Review.
Skin Appendage Disord
October 2024
Skin Health Institute, Carlton, VIC, Australia.
Introduction: Subungual acantholytic dyskeratotic acanthoma is a rare benign tumor of epidermal keratinocytes characterized by acantholysis and dyskeratosis. Only 7 other cases have been published in the literature.
Case Presentation: A 29-year-old male presented with painful erythronychia and onycholysis of the left thumbnail.
Acantholytic Dyskeratoses of the Vulva: Clinicopathologic Characterization of 16 Cases and Review of the Literature.
Int J Gynecol Pathol
August 2024
Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Article Synopsis
- The study focuses on vulvar acantholytic dyskeratoses, which are rare skin conditions affecting the vulva and perineum, with a goal to improve classification and understanding for gynecologic pathologists.
- Between 1990 and 2023, 16 cases of vulvar acantholytic dyskeratoses were analyzed, mostly affecting women aged 36 to 79, with many presenting asymptomatic or pruritic lesions predominantly on the labia majora.
- Histologically, these conditions showed features like acantholysis, with some patients responding to local excision or corticosteroids; however, no clear distinction was found between sporadic and syndromic cases based on
Article Synopsis
- Transient acantholytic dermatosis, or Grover's disease, is a skin condition that causes red, itchy bumps mainly on the trunk, mostly seen in men over 50, and can be triggered by heat, sweat, sun exposure, and some medications.
- A case study highlighted a 65-year-old man with a severe rash and a confirmed SARS-CoV-2 infection, who developed COVID-19 pneumonia, showing the link between Grover's disease and COVID-19.
- The patient’s skin lesions improved with corticosteroids, suggesting that awareness of Grover's disease in COVID-19 patients is important for diagnosis and treatment.
Darier disease: Histopathology revisited.
Indian J Pathol Microbiol
July 2024
Department of Pathology, St. John's Medical College, Bengaluru, Karnataka, India.
Article Synopsis
- Darier disease (DD) is a rare genetic skin condition primarily documented through case reports, prompting a study to systematically examine its histopathologic features in skin biopsies over 12 years.* -
- The study reviewed biopsies from 16 patients, primarily in their 30s, revealing common symptoms like hyperpigmented papules and plaques, with notable histological features including suprabasal acantholytic clefts and various unusual patterns.* -
- The study emphasizes the importance for pathologists to recognize the diverse histopathological variations of DD, particularly in atypical cases, while acknowledging its limitation due to a small sample size.*
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