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Early vs. Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation.
Am J Respir Crit Care Med
January 2025
Radbound Univeristy Medical Center, Nijmegen, Netherlands;
Rationale: In critically ill patients receiving invasive mechanical ventilation, switching from controlled to assisted ventilation is a crucial milestone towards ventilator liberation. The optimal timing for switching to assisted ventilation has not been studied.
Objectives: Our objective was to determine whether a strategy of early as compared to delayed switching affects the duration of invasive mechanical ventilation, ICU length of stay, and mortality.
Case report: Electrical impedance tomography-guided ventilator weaning in an obese patient with severe pneumonia.
Front Med (Lausanne)
January 2025
Intensive Care Unit, Zhongshan City People's Hospital, Zhongshan City, China.
Background: Electrical impedance tomography (EIT) evaluates lung function by providing continuous, real-time monitoring of regional lung ventilation distribution to guide the restoration of lung ventilation. Patients with obesity who are dependent on mechanical ventilation often struggle with weaning. This case report highlights the potential of EIT to guide the weaning of ventilator-dependent patients in an obese patient with severe pneumonia.
View Article and Find Full Text PDFOxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit: The Extubate Study: A Protocol for an Observational Study.
Respir Med
January 2025
Department of Intensive Care, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Purpose: The spontaneous breathing trial (SBT) is often performed to determine whether the patient can be extubated with a minimal risk of failure. The rapid shallow breathing index (RSBI) is an important parameter used in an SBT. However, weaning failure rates are between 15-20%.
View Article and Find Full Text PDFManagement of Mechanical Ventilation and Weaning in Critically Ill Patients with Neuromuscular Disorders.
Respir Med
January 2025
Bursa Uludag University Faculty of Medicine, Department of Anesthesiology and Reanimation, Bursa, Turkey.
Purpose: Myasthenia-gravis and Guillain-Barre-syndrome are two of the most common causes of acute and reversible neuromuscular-respiratory-failure(ARNRF), both may worsen respiratory-failure and need for invasive-mechanical-ventilation(IMV) for long-periods due to muscle-weakness. However, approitive IMV-mode for ARNRF patients that better gas-exchange and weaning in ARNRF remain unclear.
Materials And Methods: Critically-ill-patiens with IMV due to ARNRF, who could meet the weaning-criterias (after intubation for more than 7-days; difficult-weaning), between 2013, and 2023 were included in the study.
Outcome and complications in postcardiotomy cardiogenic shock treated with extracorporeal life support - a systematic review and meta-analysis.
BMC Anesthesiol
January 2025
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, 12203, Germany.
Background: Postcardiotomy cardiogenic shock (PCCS) in cardiac surgery is associated with a high rate of morbidity and mortality. Beside other therapeutic measures (e.g.
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