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Sphaeroane and neodolabellane diterpenes from the red alga Sphaerococcus coronopifolius. | LitMetric

Sphaeroane and neodolabellane diterpenes from the red alga Sphaerococcus coronopifolius.

Mar Drugs

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.

Published: May 2009

AI Article Synopsis

  • Researchers studied extracts from the red alga Sphaerococcus coronopifolius found on the rocky coasts of Corfu Island, discovering two new diterpene alcohols and a new sphaeroane diterpene.
  • The new compounds, named sphaerollanes I and II, and 16-hydroxy-9S*-acetoxy-8-epi-isosphaerodiene-2, add to the known metabolites from this alga.
  • Their structures and stereochemistry were determined through comprehensive spectral analysis, including advanced 2D-NMR techniques.

Article Abstract

Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S*-acetoxy-8-epi-isosphaerodiene-2 (3), along with two previously reported metabolites 4, 5. The structures of the new natural products, as well as their relative stereochemistry, were elucidated on the basis of extensive spectral analysis, including 2D-NMR experiments.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707042PMC
http://dx.doi.org/10.3390/md7020184DOI Listing

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