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Potential neurotoxicity associated with methotrexate.
Sci Rep
August 2024
Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Wanglang Road, Siriraj, Bangkok Noi, Bangkok, 10700, Thailand.
This study aimed to elucidate the incidence and characteristics of neurotoxicity in patients receiving methotrexate (MTX) treatment. A retrospective analysis was performed using data from the electronic cohort database spanning from January 1990 to December 2021. This review focused on patients who manifested neurotoxic symptoms post-MTX therapy, excluding patients with peripheral neuropathy.
View Article and Find Full Text PDFNeurosyphilis presenting with Guillain-Barre syndrome: a case report.
BMC Neurol
November 2023
Department of Neurosciences, University of California San Diego, San Diego, California, USA.
Background: Syphilis is associated with a wide variety of systemic presentations, earning it the moniker "The great mimicker". Neurosyphilis is classically associated with meningovasculitis in the acute-subacute stage and tabes dorsalis and dementia paralytica in later stages. However, one of the less well described presentations include Guillain-Barre Syndrome.
View Article and Find Full Text PDFTriggers of Guillain-Barré Syndrome: Predominates.
Int J Mol Sci
November 2022
Neurology & Neurophysiology Center, 1180 Vienna, Austria.
Guillain-Barré syndrome (GBS) is a rare immune-mediated acute polyradiculo-neuropathy that typically develops after a previous gastrointestinal or respiratory infection. This narrative overview aims to summarise and discuss current knowledge and previous evidence regarding triggers and pathophysiology of GBS. A systematic search of the literature was carried out using suitable search terms.
View Article and Find Full Text PDFSensory Predominant Guillain-Barré Syndrome Concomitant with Dengue Infection: A Case Report.
Case Rep Neurol
June 2022
Department of Internal Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.
Guillain-Barre syndrome is an acute demyelinating polyneuropathy disease which is autoimmune in nature and usually follows gastrointestinal or respiratory infections. Dengue fever is however not a common trigger to the condition. Here, we report a patient who developed sensory predominant demyelinating polyradiculopathy during febrile phase of dengue fever.
View Article and Find Full Text PDFNeurological manifestations in people living with HIV/AIDS in the late cART era: a prospective observational study at a tertiary healthcare center in São Paulo, Brazil.
HIV Res Clin Pract
August 2021
Departamento de Infectologia, Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brazil.
The aim of this study was to evaluate the frequency, spectrum, in-hospital mortality rate, and factors associated with death in people living with HIV/AIDS (PLWHA) presenting with neurological diseases from a middle-income country, as well as estimate its one-year global death rate.This prospective observational cohort study was conducted at a Brazilian tertiary health center between January and July 2017. HIV-infected patients above 18 years of age who were admitted due to neurological complaints were consecutively included.
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