Collagenous fibroma (desmoplastic fibroblastoma) with a new translocation involving 11q12: a case report.

Cancer Genet Cytogenet

Department of Pathology and Laboratory Medicine, University Hospital, New Jersey Medical School, 150 Bergen Street, Newark, NJ 07103, USA.

Published: July 2009

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Collagenous fibroma (or desmoplastic fibroblastoma) is a rare, benign tumor usually centered in the subcutaneous tissue composed of spindle-shaped to stellate fibroblasts and myofibroblasts in a densely collagenous background. Three previous case reports have described a t(2;11)(q31;q12) in this entity. Herein, we report a case of collagenous fibroma of deep soft tissue with t(11;17)(q12;p11.2). The breakpoint at chromosome 11q12 appears to be pathogenetic in this rare neoplasm.

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http://dx.doi.org/10.1016/j.cancergencyto.2009.03.012DOI Listing

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