AI Article Synopsis
- * CSF samples from 11 SAH patients showed elevated SPC levels on days 3, 8, and 14 post-hemorrhage compared to normal CSF, indicating a significant change due to SAH.
- * In dogs, SPC was rapidly diluted in the CSF after injection, suggesting that SPC is released in larger amounts than the measurements indicated, reinforcing its potential role in cerebral vasospasm development.
Article Abstract
This study investigates the role of sphingosylphosphorylcholine (SPC) in the mechanisms underlying cerebral vasospasm after subarachnoid hemorrhage (SAH). The levels of SPC were measured in cerebrospinal fluid (CSF) of patients with SAH and also in an experimental canine model. CSF samples were collected from 11 patients with SAH, and from dogs that had received an injection of SPC into the cisterna magna to examine SPC kinetics in the CSF. SPC was assayed using solid-phase extraction and triple quadrupole mass spectrometry. The SPC concentrations in SAH patients on days 3, 8, and 14 after the onset of SAH were significantly higher than those in normal CSF. In the canine model, rapid dilution of SPC in CSF was observed. In combination with data from previous studies, these results suggest that SPC is involved in the development of cerebral vasospasm. Rapid dilution of SPC in CSF suggests that SPC is released into CSF at higher concentrations than those measured in the present study.
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| http://dx.doi.org/10.1016/j.jocn.2009.01.010 | DOI Listing |
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