1,25(OH)2D3 enhances myocardial contractility with pharmacological doses from 1 to 20 micrograms within 30-60 min. dp/dt modifications induced by 1,25(OH)2D3 are dose dependent and approach linearity from 1 to 10 micrograms. The inotropic effects are not dependent on extracellular Ca2+ levels; but cellular Ca2+ influx or internal Ca2+ movement may be implied. The effect seems not related to the described 1,25(OH)2D3 receptors which implies protein de novo synthesis. A modulation on other receptor-mediated substances acting on Ca2+ movements seems probable.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000420127 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis.
Transplant Proc
June 2004
Children's Memorial Health Institute, Warsaw, Poland.
Reports of bone mineral density in children after liver transplantation are few. Eleven cholestatic children were analyzed before and 6 months after liver transplantation. No changes in serum levels of calcium, alkaline phosphates, or 25OHD were observed before versus after LTx.
View Article and Find Full Text PDFCyclosporin A increases somatomedin C insulin-like growth factor I levels in chronic rheumatic diseases.
J Rheumatol
June 1995
Department of Internal Medicine, School of Medicine, General Hospital, Udine, Italy.
Objective: To determine whether anabolic hormones that affect the musculoskeletal system and active on the immune cells changed during cyclosporin A (CysA) therapy.
Methods: We carried out a randomized study of patients with rheumatic disease attending the outpatient clinic for rheumatic diseases. Twenty-four patients with chronic arthritis [20 with rheumatoid arthritis (RA) and 4 with psoriatic arthritis (PsA)] were divided into 2 groups (10 RA, 2 PsA) and randomly given CysA 5 mg/kg daily or hydroxychloroquine (OH-Chlor) 6 mg/kg daily in divided doses.
Ten stable, normocalcemic renal transplant patients with good allograft function, hyperparathyroidism, and variable hypophosphatemia were treated for 2 to 9 months with oral calcium carbonate and replacement doses of vitamin D analogues. Parathyroid hormone levels (PTH) and renal phosphate wasting were not autonomous or fixed but decreased with therapy. Although serum 1-25(OH)2D3 levels could be shown to rise appropriately during oral vitamin D therapy and fall afterwards, a separate study in a larger group of patients showed no effect of elevated parathyroid hormone or hypophosphatemia to increase endogenous 1-25(OH)2D3 levels.
View Article and Find Full Text PDFCharacterization and induction of a cell line established from a patient with erythroleukemia (FAB M6).
Nihon Ketsueki Gakkai Zasshi
February 1990
Blood Transfusion Service, Fukushima Medical College, Japan.
A human cell line, designated as NISI, was established from a patient with erythroleukemia (FAB M6). The presence of a chromosome marker in NISI line indicates that it is derived from the leukemic clone which bears the common marker. The cell line shows morphology of immature erythroblast and has myelocytic properties from surface immunophenotyping.
View Article and Find Full Text PDF[Evaluation of the effect of premenopausal oophorectomy on bone mineral content].
Nihon Sanka Fujinka Gakkai Zasshi
March 1989
Department of Obstetrics and Gynecology, Yokosuka Kyosai Hospital, Kanagawa.
The effects of premenopausal oophorectomy on bone mineral content (BMC) and serum parameters of bone metabolism, ie E2, PTH, Ca, P, ALP, BGP, 1-25(OH)2D3 were studied. The BMC of the spongiosum of L-3 vertebral body was calculated by means of computed tomography which was utilized in conjunction with a calibrated phantom containing a set of reference densities (CaCO3). The BMC tended to decrease markedly in the late 40s (r = -0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!