Theta-Modulated Input Reduces Intrinsic Gamma Oscillations in a Hippocampal Model.

Neurocomputing (Amst)

Department of Neurosurgery, University of Virginia, Charlottesville, VA.

Published: June 2007

Introducing theta-modulated input into a minimal model of the CA3 region of the hippocampus has significant effects on gamma oscillations. In the absence of theta-modulated input, the gamma oscillations are robust across a range of parameters. Introducing theta-modulated input weakens the gamma oscillations to a power more consistent with power spectra acquired from laboratory animals. With these changes, simulations of the hippocampal model are able to reproduce hippocampal power spectra measured in awake mice.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707940PMC
http://dx.doi.org/10.1016/j.neucom.2006.10.086DOI Listing

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