Adalimumab-induced autoimmune hepatitis.

J Clin Gastroenterol

Liver Unit, Division of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Published: January 2010

AI Article Synopsis

  • Antitumor necrosis factor antibodies, like adalimumab, are commonly used for autoimmune diseases.
  • A case was reported where a patient developed autoimmune hepatitis while being treated with adalimumab for psoriatic arthritis.
  • The patient fully recovered after stopping adalimumab and receiving steroid treatment, marking the first documented case of autoimmune hepatitis caused by this medication.

Article Abstract

Antitumor necrosis factor antibodies are widely used in the treatment of autoimmune diseases. We describe the occurrence of autoimmune hepatitis in a patient treated with adalimumab, a fully human IgG antibody against tumor necrosis factor, for psoriatic arthritis. The patient made a full recovery after discontinuation of adalimumab and treatment with steroids. This is the first reported case of adalimumab-induced autoimmune hepatitis.

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Source
http://dx.doi.org/10.1097/MCG.0b013e3181a745e7DOI Listing

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