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Modern biology of extrachromosomal DNA: A decade-long voyage of discovery.
Cell Res
January 2025
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Genomic instability is a hallmark of cancer and is a major driving force of tumorigenesis. A key manifestation of genomic instability is the formation of extrachromosomal DNAs (ecDNAs) - acentric, circular DNA molecules ranging from 50 kb to 5 Mb in size, distinct from chromosomes. Ontological studies have revealed that ecDNA serves as a carrier of oncogenes, immunoregulatory genes, and enhancers, capable of driving elevated transcription of its cargo genes and cancer heterogeneity, leading to rapid tumor evolution and therapy resistance.
View Article and Find Full Text PDFA Postmodernist Qualitative Research Approach: Choosing Between Descriptive and Interpretive Phenomenology.
J Adv Nurs
December 2024
College of Nursing, Brigham Young University, Provo, Utah, USA.
Introduction: Phenomenology is essential for researchers exploring human experience. To apply it rigorously, an understanding of its philosophical foundations is needed. This discussion outlines the key distinctions between interpretive and descriptive phenomenology to illustrate philosophical and methodological implications.
View Article and Find Full Text PDFCross-Standard Health Data Harmonization using Semantics of Data Elements.
Sci Data
December 2024
Amsterdam UMC location University of Amsterdam, Department of Medical Informatics, Amsterdam, 1105, AZ, The Netherlands.
Faced with heterogeneity of healthcare data, we propose a novel approach for harmonizing data elements (i.e., attributes) across health data standards.
View Article and Find Full Text PDFA scoping review of autoethnography in nursing.
Int J Nurs Sci
November 2024
Department of Caring Sciences, Faculty of Health and Occupational Studies, University of Gävle, Sweden.
Objective: Autoethnography combines personal experiences with cultural analysis, emerging as a response to the limitations of traditional ethnography. This review aimed to explore, describe, and delineate the utilization of autoethnography by nurses published in peer-reviewed journals.
Methods: A scoping review was conducted according to the Arksey and O'Malley framework.
Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network.
Front Immunol
December 2024
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Background: Adults classified as immunosuppressed have been disproportionately affected by the COVID-19 pandemic. Compared to the immunocompetent, certain patients are at increased risk of suboptimal vaccine response and adverse health outcomes if infected. However, there has been insufficient work to pinpoint where these risks concentrate within the immunosuppressed spectrum; surveillance efforts typically treat the immunosuppressed as a single entity, leading to wide confidence intervals.
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