In this retrospective observational study involving 176 patients and 271 biopsies, the histologic differentiation in superficial endometriosis, deeply infiltrating endometriosis, and ovarian endometriomas was evaluated according to a previously proposed classification system. Results showed a predominance of the undifferentiated glandular pattern (33.5%) and mixed glandular pattern (46.9%) in deeply infiltrating endometriosis lesions, whereas the well-differentiated glandular pattern (41.8%) was most frequently seen in superficial endometriosis lesions, and in ovarian endometriomas a predominance of both the undifferentiated (40.5%) and mixed patterns (37.8%) was observed.
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Visual-Numeric Endometriosis Scoring System (VNESS) for mapping surgical findings: A validation study.
Facts Views Vis Obgyn
December 2024
Background: Several endometriosis classification systems have been proposed and published but the search for a universal language that communicates the complexity, laterality and severity of this disease continues. The authors introduce the Visual-Numeric Endometriosis Scoring System. VNESS is a novel system for describing surgical findings in each compartment of the pelvis in a way that is simple to use, visually intuitive and mirrors a laparoscopic image of the pelvis.
View Article and Find Full Text PDFValidation of administrative health data for the identification of endometriosis diagnosis.
Hum Reprod
December 2024
Department of Family and Preventative Medicine, University of Utah, Salt Lake City, UT, USA.
Study Question: How do endometriosis diagnoses and subtypes reported in administrative health data compare with surgically confirmed disease?
Summary Answer: For endometriosis diagnosis, we observed substantial agreement and high sensitivity and specificity between administrative health data-International Classification of Diseases (ICD) 9 codes-and surgically confirmed diagnoses among participants who underwent gynecologic laparoscopy or laparotomy.
What Is Known Already: Several studies have assessed the validity of self-reported endometriosis in comparison to medical record reporting, finding strong confirmation. We previously reported high inter- and intra-surgeon agreement for endometriosis diagnosis in the Endometriosis, Natural History, Diagnosis, and Outcomes (ENDO) Study.
Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study.
Hum Reprod
December 2024
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
Study Question: Is there an association between the somatic loss of PTEN (phosphatase and tensin homolog) and ARID1A (AT-rich interaction domain 1A) and endometriosis disease severity and worse clinical outcomes?
Summary Answer: Somatic PTEN loss in endometriosis epithelium was associated with greater disease burden and subsequent surgical complexity.
What Is Known Already: Somatic cancer-driver mutations including those involving the PTEN and ARID1A genes exist in endometriosis without cancer; however, their clinical impact remains unclear.
Study Design, Size, Duration: This prospective longitudinal study involved endometriosis tissue and clinical data from 126 participants who underwent surgery at a tertiary center for endometriosis (2013-2017), with a follow-up period of 5-9 years.
Perinatal and infant outcomes following ART treatment for endometriosis alone compared with other causes of infertility: a data linkage cohort study.
Fertil Steril
December 2024
School of Clinical Medicine, Faculty of Medicine, University of New South Wales, Sydney, Australia; Gynaecological Research and Clinical Evaluation (GRACE) Group, Royal Hospital for Women and University of New South Wales, Sydney, Australia.
Objective: To evaluate whether perinatal and infant outcomes differ between singleton births following assisted reproductive technology (ART) in women with endometriosis alone and those with other causes of infertility.
Design: Population-based data linkage cohort study.
Subjects: A total of 29,152 ART-conceived singleton births from 24,116 mothers, 2010-2017, New South Wales, Australia.
Management of endometriosis: a call to multidisciplinary approach.
J Osteopath Med
December 2024
Department of Medical and Surgical Gynecology, Mayo Clinic, Phoenix, AZ, USA.
Article Synopsis
- Endometriosis is characterized by the growth of endometrial-like tissue outside the uterus, classified into three types: superficial, ovarian endometrioma, and deep infiltrating disease, and can affect various areas beyond the pelvis.
- Diagnosis typically involves a combination of symptom assessment, physical exams, imaging tests, and ultimately requires tissue confirmation for a definitive diagnosis.
- Treatment options range from medical management focused on symptom relief to surgical interventions, with a preference for excision of lesions and a multidisciplinary approach for more severe cases to enhance long-term outcomes.
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