The development of new sources of coherent non-ionizing radiation in terahertz wave range put forward the basic problems of revealing the mechanism of its action on biological objects, especially, on the nervous system. At this point it is necessary to reveal the radiation effects on complex molecular systems such as nerve cells. It was the main objective of this study. In the previous study we were the first to demonstrate highly specific effects of some examined wavelengths on the structural-functional properties of the nerve cells. The radiation of a free-electron laser produced damage to neuron morphology dependent on the power and wavelength. Transparent blank protrusions of the membrane, disorders of the growth of processes, and fall of the membrane potential were observed. The model developed and the data obtained approach the understanding of the molecular mechanisms of the effect of the waves under study on cells. These waves can be probably used as a tool for further investigation of functioning of neurons and neural system and correction of some pathology.
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Viruses
December 2024
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Chikungunya virus (CHIKV) is an emerging, mosquito-borne arthritic alphavirus increasingly associated with severe neurological sequelae and long-term morbidity. However, there is limited understanding of the crucial host components involved in CHIKV replicase assembly complex formation, and thus virus replication and virulence-determining factors, within the central nervous system (CNS). Furthermore, the majority of CHIKV CNS studies focus on neuronal infection, even though astrocytes represent the main cerebral target.
View Article and Find Full Text PDFPharmaceutics
December 2024
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University, 18 Kremlyovskaya St., 420008 Kazan, Russia.
The combination of macroporous cryogels with synthetic peptide factors represents a promising but poorly explored strategy for the development of extracellular matrix (ECM)-mimicking scaffolds for peripheral nerve (PN) repair. In this study, IKVAV peptide was functionalized with terminal lysine residues to allow its in situ cross-linking with gelatin macromer, resulting in the formation of IKVAV-containing proteinaceous cryogels. The controllable inclusion and distribution of the peptide molecules within the scaffold was verified using a fluorescently labelled peptide counterpart.
View Article and Find Full Text PDFPolymers (Basel)
December 2024
Department of Neurological Surgery, The University of Washington, Seattle, WA 98109, USA.
Spinal cord trauma leads to the destruction of the highly organized cytoarchitecture that carries information along the axis of the spinal column. Currently, there are no clinically accepted strategies that can help regenerate severed axons after spinal cord injury (SCI). Hydrogels are soft biomaterials with high water content that are widely used as scaffolds to interface with the central nervous system (CNS).
View Article and Find Full Text PDFToxics
November 2024
College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
The highly hazardous chemical ammonia has been proven to be absorbed by nanoparticles, thereby exerting highly toxic effects on aquatic organisms. As a ubiquitous pollutant in aquatic environments, polystyrene nanomicroplastics (PSNPs) have shown strong adsorption capacity due to their large surface area. Therefore, the potential joint effects of ammonia and PSNPs need to be clarified.
View Article and Find Full Text PDFNutrients
December 2024
Department of Nutrition, Dietetics and Food, School of Clinical Sciences, Monash University, Notting Hill, VIC 3168, Australia.
The brain is a lipid-rich organ, mainly due to the very high lipid content of myelin, but in addition to this, all the neuronal cell membranes, of which there are over 80 billion in the human brain [...
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