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Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence.
J Nanobiotechnology
January 2025
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, P.R. China.
Background: Osteoarthritis (OA) is a degenerative joint disease with an immense unmet medical need. FGF18 protein is a potential regenerative factor for cartilage repair. However, traditional protein delivery methods have limited efficacy due to the short lifetime and shallow infiltration.
View Article and Find Full Text PDF4-Hydroxynonenal from Mitochondrial and Dietary Sources Causes Lysosomal Cell Death for Lifestyle-Related Diseases.
Nutrients
November 2024
Department of Psychiatry and Behavioral Science, Kanazawa University Graduate School of Medical Sciences, Takara-machi 13-1, Kanazawa 920-8040, Japan.
Excessive consumption of vegetable oils such as soybean and canolla oils containing ω-6 polyunsaturated fatty acids is considered one of the most important epidemiological factors leading to the progression of lifestyle-related diseases. However, the underlying mechanism of vegetable-oil-induced organ damage is incompletely elucidated. Since proopiomelanocortin (POMC) neurons in the hypothalamus are related to the control of appetite and energy expenditure, their cell degeneration/death is crucial for the occurrence of obesity.
View Article and Find Full Text PDFCausal linkage of Graves' disease with aging: Mendelian randomization analysis of telomere length and age-related phenotypes.
BMC Geriatr
October 2024
Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Background: Aging is an irreversible progressive decline in physical function. Graves' disease (GD) is a common cause of hyperthyroidism and is characterized by elevated levels of the thyroid hormone (TH). High TH levels are associated with aging and a shortened lifespan.
View Article and Find Full Text PDFVitamin D levels and risk of ocular disorders: insights from bidirectional and multivariable Mendelian randomization analysis.
Front Med (Lausanne)
October 2024
Department of Ophthalmology, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Article Synopsis
- - This study examined how vitamin D levels might influence various eye disorders using genetic data from large research studies involving over 700,000 European individuals.
- - Results indicated a causal link between higher genetically predicted vitamin D levels and an increased risk of wet age-related macular degeneration (WAMD), while most other ocular disorders showed no significant association.
- - The findings suggest that vitamin D could play a role in WAMD, providing valuable insights for future research and potential interventions in eye health.
Pinpointing Novel Plasma and Brain Proteins for Common Ocular Diseases: A Comprehensive Cross-Omics Integration Analysis.
Int J Mol Sci
September 2024
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, 44, Wenhuaxi Road, Jinan 250012, China.
The pathogenesis of ocular diseases (ODs) remains unclear, although genome-wide association studies (GWAS) have identified numerous associated genetic risk loci. We integrated protein quantitative trait loci (pQTL) datasets and five large-scale GWAS summary statistics of ODs under a cutting-edge systematic analytic framework. Proteome-wide association studies (PWAS) identified plasma and brain proteins associated with ODs, and 11 plasma proteins were identified by Mendelian randomization (MR) and colocalization (COLOC) analyses as being potentially causally associated with ODs.
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