Objectives: To measure the contralateral renal parenchymal volume (RPV) before and after nephrectomy and investigate the factors influencing compensatory hypertrophy. Unilateral nephrectomy induces compensatory hypertrophy in the contralateral kidney.
Methods: From December 2003 to January 2008, 142 patients undergoing nephrectomy were enrolled in this study. All patients underwent preoperative technetium-99m dimercaptosuccinic acid renal scintigraphy. The percentage of technetium-99m dimercaptosuccinic acid uptake in the resected kidney was 37.2% +/- 15.3%. Contrast-enhanced computed tomography was performed preoperatively and 1 week and 6 months postoperatively, and RPV was calculated as the normally functioning tissue, excluding tumors or nonenhanced areas.
Results: The mean RPV of the remaining kidney was 164.2 cm(3) preoperatively and 184.1 and 178.8 cm(3) at 1 week and 6 months postoperatively, respectively. Multivariate regression analysis revealed that the increase in RPV was positively associated with the percentage of technetium-99m dimercaptosuccinic acid uptake in the resected kidney (P < .001) and negatively associated with patient age (P = .008). Logistic regression analysis showed that the group with an RPV increase of <15% had a 4.1-fold increased risk of a 10% decrease in the glomerular filtration rate during the next 6 postoperative months compared with the risk in the group with an RPV increase of >or=15% (P = .004).
Conclusions: The change in contralateral RPV occurred during the first week after nephrectomy and remained stable for >or=6 months. The change in RPV increased when the removed kidney had greater function and decreased with increasing patient age. The risk of progression to renal insufficiency can be predicted according to the change in RPV.
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http://dx.doi.org/10.1016/j.urology.2008.11.008 | DOI Listing |
J Infect Chemother
December 2024
Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
The incidence of urinary tract infection (UTI) caused by extensive beta-lactamase-producing Escherichia coli (ESBL-EC) is increasing, including in children. However, the available oral antibiotic treatment options for ESBL-EC are limited. Herein, we report the cases of two children diagnosed with UTI caused by ESBL-EC (ESBL-UTI) who were switched from empirical intravenous antibiotics in UTI to amoxicillin-clavulanic acid (AMPC/CVA) (14:1) after the causative organism was found to be ESBL-EC.
View Article and Find Full Text PDFJ Pak Med Assoc
November 2024
Nuclear Medicine Department, East Kent University Hospitals NHS Foundation Trust, UK.
Cureus
July 2024
Department of Pediatric Rheumatology and Nephrology, Çanakkale Onsekiz Mart University, Faculty of Medicine, Çanakkale, TUR.
Background Ureteropelvic junction stenosis (UPJS) is the most common cause of clinically significant antenatal hydronephrosis. We compared separate renal function results obtained using technetium-99m-mercaptoacetyltriglycine (Tc-99m MAG-3) and technetium-99m-dimercaptosuccinic acid (Tc-99m DMSA) in pediatric patients with UPJS to evaluate the adequacy of Tc-99m MAG-3 scintigraphy and the necessity of additional Tc-99m DMSA scintigraphy during follow-up. Methodology Patients diagnosed with hydronephrosis in the Pediatric Nephrology Department of Pamukkale University Faculty of Medicine over a period of 10 years (2012-2022) were evaluated retrospectively.
View Article and Find Full Text PDFChemosphere
September 2024
Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, 01812, Republic of Korea; Radiological and Medico-Oncological Sciences, University of Science and Technology (UST), Seoul, 01812, Republic of Korea. Electronic address:
In the previous study (Im et al., 2022), we revealed microplastic (MP) was accumulated and cleared through the kidneys via PET imaging. Here, we aimed to identify the renal dysfunction due to polyethylene (PE) MP in the kidney tissue.
View Article and Find Full Text PDFJ Nucl Med Technol
September 2024
Department of Radiology, Harvard Medical School, Boston, Massachusetts;
Tc-labeled dimercaptosuccinic acid (Tc-DMSA) imaging is a well-established and highly sensitive method for the diagnosis of several renal cortical disorders affecting children and adults. Beginning in 2014, Tc-DMSA availability was severely impaired when it was added to the Drug Shortages List of the U.S.
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