AI Article Synopsis
- - The cancer stem cell (CSC) hypothesis states that CSCs are central to cancer development, metastasis, and recurrence.
- - In a study using a 4T1 mouse model of breast cancer, researchers found that CSCs with a Sca-1 positive phenotype had increased levels of activated Ras and phosphorylated MEK.
- - Inhibiting Ras activation with a farnesylation inhibitor (FTI-277) reduced the growth of CSCs, suggesting that targeting Ras could be a promising approach for cancer treatment.
Article Abstract
The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer and cause cancer metastasis and recurrence. In this study, we examined whether Ras signaling is associated with stemness of the CSCs population characterized by the stem cell antigen (Sca-1) phenotype in a 4T1 syngeneic mouse model of breast cancer. The Sca-1(pos) putative CSCs had high levels of activated Ras and phosphorylated MEK (p-MEK), compared with counterparts. The Ras farnesylation inhibitor (FTI-277) suppressed the maintenance and expansion of CSCs. Therefore, selective inhibition of Ras activation may be useful for stem-specific cancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291698 | PMC |
| http://dx.doi.org/10.1016/j.canlet.2009.06.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!