There are abundant theories in the scientific literature that propose a range of pathophysiological pathways for preeclampsia. In this review we discuss some of the contributions made to this field from the perspective of a placental developmental biology laboratory. We discuss an underlying immune component of preeclampsia associated with expression of HLA-G and also a beneficial function of decidual NK cells. We conclude by summarizing newer findings regarding the anti-angiogenic expression of soluble fms-like tyrosine kinase (sFlt-1) and its role in the development of preeclampsia.
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| http://dx.doi.org/10.1016/j.jri.2009.05.002 | DOI Listing |
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