Access to flavones via a microwave-assisted, one-pot Sonogashira-carbonylation-annulation reaction.

Org Lett

Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1.

Published: August 2009

Palladium complexes of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane are shown to be effective catalytic systems facilitating the sequential application of a microwave-assisted Sonogashira and carbonylative annulation reaction for the preparation of substituted flavones.

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http://dx.doi.org/10.1021/ol901043qDOI Listing

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