AI Article Synopsis
- The study aimed to evaluate the effectiveness and side effects of combining docetaxel and nedaplatin as induction chemotherapy for patients with operable oral squamous cell carcinoma.
- A total of 30 patients underwent one cycle of chemotherapy, resulting in 33.3% achieving partial clinical response and 56.6% showing positive histological response.
- Despite 90% experiencing severe neutropenia, severe infections were rare, suggesting the treatment is manageable and may support further studies that explore additional cycles of therapy before surgery.
Article Abstract
Purpose: To determine the clinical and hisotological efficacy and toxicities of induction chemotherapy with docetaxel (DOC) and nedaplatin (CDGP) for oral squamous cell carcinoma (OSCC) in the preoperative setting.
Methods: A total of 30 patients with locally advanced but operable OSCC were enrolled. Combination induction chemotherapy consisted of DOC 60 mg/m2 followed by CDGP 100 mg/m2.
Results: All patients received one cycle of chemotherapy. In the clinical assessment, ten patients achieved partial response for an overall response rate of 33.3% (95% CI, 16.4-50.2%). Histological assessment of surgical specimens showed an overall response rate of 56.6% (95% CI, 38.9-74.3%). Although severe neutropenia was observed in 90% of patients, only one patient (3.3%) experienced severe infection. Toxicities associated with this regimen did not interfere with planned radical surgery.
Conclusions: A single cycle of preoperative combination chemotherapy with DOC and CDGP showed moderate histological activity with an acceptable safety profile for the planned radical surgery. Further studies testing more cycles before surgery might be more appropriate.
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| http://dx.doi.org/10.1007/s00280-009-1056-z | DOI Listing |
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