Our objective was to evaluate the effects of a reservoir-type calcitriol (5 mg/animal) transdermal patch on plasma calcitriol and calcium (Ca) concentrations in dairy cattle. A group of six heifers received three different types of patches: an encapsulated reservoir solution containing calcitriol alone (CAL), calcitriol with dodecylamine (CAL+D), or vehicle (CONT). The patches were applied to the skin of the tail for duration of 2 days at intervals of at least 3 weeks. Cattle that received CAL or CAL+D showed significant increases in plasma calcitriol and Ca concentrations on day 2 and days 2 and 3, respectively. The areas under the plasma concentration-time curve (AUC) values for plasma calcitriol and Ca in the CAL and CAL+D groups increased significantly compared to the CONT group. The data of this study describe evidence of measurable transdermal absorption of exogenous calcitriol from a patch and its sufficient biological action to elevate plasma Ca concentrations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1292/jvms.71.845 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Influence of Nordic Walking Training on the Serum Levels of Sirtuins, FOXO3a, and Vitamin D Metabolites in Patients with Multiple Myeloma.
Curr Oncol
December 2024
Institute for Basic Sciences, Faculty of Physiotherapy, University of Physical Education, 31-571 Krakow, Poland.
Background: Multiple myeloma, a malignancy of plasma cells, often involves the disruption of vitamin D metabolism. Vitamin D, acting through its receptor (VDR), affects transcription factors like FOXO and sirtuins, which regulate cellular processes. The impact of physical activity on these markers in multiple myeloma patients is unclear.
View Article and Find Full Text PDFThe association between vitamin D receptor gene polymorphism FokI and type 2 diabetic kidney disease and its molecular mechanism: a case control study.
BMC Med Genomics
December 2024
Department of International Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Background: The role of the vitamin D receptor single nucleotide polymorphism FOKI (VDR-FOKI) (rs2228570) in genetic susceptibility to type 2 diabetic kidney disease (T2DKD) remains uncertain. This study investigated the relationship between VDR-FOKI and T2DKD within the Chinese Plateau Han population and analyzed the underlying mechanisms.
Methods: A total of 316 subjects were enrolled, including 44 healthy adults, 114 individuals with type 2 diabetes mellitus (T2DM), and 158 patients with T2DKD.
Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels.
Pflugers Arch
November 2024
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Increased dietary inorganic phosphate (P) intake stimulates renal P excretion, in part, by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) or dopamine. High dietary P may also stimulate sympathetic outflow. Rodent studies provided evidence for these regulatory loops, while controlled experiments in healthy humans examined periods of either a few hours or several weeks, and often varied dietary calcium intake.
View Article and Find Full Text PDFCase report: Familial hypoparathyroidism with elevated parathyroid hormone due to an inactivating mutation.
Front Endocrinol (Lausanne)
October 2024
Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Article Synopsis
- This report investigates a family with familial isolated hypoparathyroidism (FIH), highlighting a specific mutation that leads to high levels of functionally inactive parathyroid hormone (PTH) in a 34-year-old woman and her siblings.* -
- The siblings were diagnosed with pseudohypoparathyroidism type 1b, characterized by chronic low calcium levels and elevated PTH, but without the typical features of related disorders.* -
- Treatment with teriparatide, a recombinant human PTH, successfully normalized calcium levels and improved wellbeing for the patient, indicating that inactive variants of PTH can lead to complex hypocalcemia cases.*
[Vitamin D status in connection with and genes polymorphism in coal mining workers].
Vopr Pitan
October 2024
Kemerovo State University, 650000, Kemerovo, Russian Federation.
Vitamin D is a unique compound that can enter the human body not only with food, but also be synthesized in the skin under the influence of ultraviolet radiation. Individual differences in the need for this vitamin may be associated with the carriage of polymorphic variants of genes that implement its biological effects, which include VDR BsmI C>T (rs1544410), VDR TaqI A>G (rs731236) and GC rs2282679 T>G. At risk for vitamin D deficiency are workers in the coal mining industry, whose working conditions combine limited insolation and a pronounced deficiency of vitamins in the diet.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!